IMAGING SUPPORT FOR APOLLO 5, MOONSHOT

《21世纪世纪治愈法》于2016年12月签署成为法律，专门提供新的资金来支持与博·拜登癌症登月计划有关的努力。 登月计划的一个关键组成部分是呼吁联邦机构合作。 2016年的最初公告特别提到了国防部和退伍军人事务部的医疗保健团体。 应用蛋白质基因组学组织学习和成果（APOLLO）是一个专门从登月活动中产生的项目，它直接解决了实现联邦跨机构合作的目标，将国防部（DoD），退伍军人事务部（VA）和NCI聚集在一起，共同努力改善癌症患者的生活。 APOLLO解决的moonshot目标涵盖了癌症研究的范围（NCI组件-蛋白质组学/蛋白质基因组学，成像和发现），通过潜在地改变DoD和VA医疗保健系统中患者的护理方式。它专门针对2016年蓝丝带小组（BRP）的建议，通过建立过程，程序，数据共享以及政府临床医生和基础科学家之间的合作来建立国家癌症数据生态系统。 APOLLO项目于2016年夏季启动，包括5个子项目。 四个是回顾性试点与现有的患者临床信息和癌症组织从退伍军人管理局，国防部和他们的学术合作者。这些项目涉及肺癌，妇科，乳腺癌，前列腺癌。 第五个项目（本提案的重点）是在国防部、退伍军人事务部及其学术合作者的多个地点进行的前瞻性试验。 该项目（APOLLO 5）将涵盖约8000名患者的实体瘤。 将积累长期随访、临床、成像和组织采样。 正在设计各种系统，以容纳这些数据收集。 该任务令的重点是将APOLLO 5图像储存库与其他现有APOLLO数据储存库整合起来，以供分析。 这需要收集，管理和存档APOLLO相关的临床图像（包括体内和组织学图像）到现有的公共资源，癌症成像档案（TCIA）中，以便使它们与所有APOLLO分析中的基因组，蛋白质组学和临床数据相关联。

The 21st Century Cures Act was signed into law in December 2016 dedicating new funds to support efforts associated with the Beau Biden Cancer Moonshot Initiative. A key component of the moonshot effort is a call for federal agencies to work together. The initial announcement in 2016 specifically referenced the DOD and the VA health care groups. The Applied Proteogenomics Organizational Learning and Outcomes (APOLLO,) a project arising specifically out of the moonshot activities, directly addresses the goal of achieving federal cross-agency collaboration by bringing together the Department of Defense (DoD), the Department of Veterans Affairs (VA), and the NCI to work together to improve cancer patient lives. The moonshot goals that APOLLO addresses cover the spectrum of cancer research (the NCI component-proteomics/proteogenomics, imaging and discovery) through potentially transforming how patients are cared for within the DoD and VA healthcare systems. It specifically addresses the 2016 Blue Ribbon Panel (BRP) recommendation to build a national cancer data ecosystem by establishing processes, procedures, data commons and collaborations among clinicians and basic scientists across the government. The APOLLO project was initiated in the summer of 2016 and comprises 5 subprojects. Four are retrospective pilots with existing patient clinical information and cancer tissue from the VA, the DOD and their academic collaborators. These projects involve lung, gynecological, breast, prostate cancers. The fifth project (the focus of this proposal) is a prospective trial in multiple sites across the DOD, the VA and their academic collaborators. This project (APOLLO 5) will encompass solid tumors in approximately 8000 patients. Long term follow-up, clinical, imaging, and tissue sampling will be accumulated. Systems are being designed to accommodate these data collections. The focus of this Task Order is the integration of the APOLLO 5 image repository with other existing APOLLO data repositories for analysis. This entails the collection, curation and archiving of APOLLO-associated clinical images (both in vivo and histology images) into an existing public resource, The Cancer Imaging Archive (TCIA), in order to make them available for correlation with the genomic, proteomic, and clinical data in all APOLLO analyses.