Development of An Optoelectronically Active Bioink

项目摘要 作为最重要的器官之一，心脏作为一个强有力的生物泵，积极地输送/输送血液， 血液通过血管系统流向/流出所有其他器官。它一直是治疗的焦点， 通过组织工程和再生医学来治疗受伤或患病的心脏。具有多年 经过努力，心脏组织工程领域在制造功能性心脏瓣膜方面取得了巨大进展。 心脏组织在很大程度上概括了心脏的生物学，但挑战仍然存在。的 心肌细胞排列成束，其特征是自发和 同步收缩使生物学相关心脏组织的发育复杂化。成熟和 心肌细胞的收缩是另一个主要障碍。本拟议项目的总体目标是 开发一种光电活性生物墨水，使其能够有效成熟和按需起搏。 生物打印的心脏组织通过不受约束的和远程光照明，以解决未满足的 迫切需要生物打印具有嵌入式远程刺激/起搏功能的心脏组织。生物墨水会 允许通过以超薄颗粒形式集成μ太阳能电池来进行光能的电转换 对于原位光诱导电刺激，其中小球也将被设计为可生物降解的， 与组织成熟的速度相匹配。

Project Summary As one of the most vital organs, the heart functions as a potent biological pump that actively delivers/recycles the blood towards/from all other organs through the vascular system. It has always been a focus in healing an injured or diseased heart through tissue engineering and regenerative medicine. With many years of endeavors, the field of cardiac tissue engineering has seen tremendous progress in fabricating functional cardiac tissues that to a great extent recapitulate the biology of the heart, but challenges remain. The alignment of cardiomyocytes and their organization into bundles characterized by spontaneous and synchronous contraction complicate the development of biologically relevant cardiac tissues. Maturation and contraction of the cardiomyocytes poses another major obstacle. The overall goal of this proposed project is to develop an optoelectronically active bioink that will enable effective maturation and on-demand pacing of the bioprinted cardiac tissues through untethered and remote photo-illumination, in order to address the unmet urgent needs in bioprinting cardiac tissues with embedded, remote stimulation/pacing functions. The bioink will allow for electrical conversion of photoenergy through integration of μ-solar cells in the form of ultra-thin pellets for in situ photo induced electrical stimulation, where the pellets will also be designed to be biodegradable to match the rate of tissue maturation.