A Digital Therapeutic to Advance the Delivery of Effective Interventions for Suicide Prevention

摘要 自杀是美国十大死因之一，在过去的二十年里，自杀率稳步上升 好几年了。尽管如此，关于旨在减少自杀企图的治疗方案的研究还很少。 而且没有一个包括数字治疗。在这个第一阶段的SBIR应用OUI治疗公司中，LLC提出了一种 项目目标：1)创建Oui应用程序的测试版(称为“Aviva”)，这是一款基于CBT的数字疗法，以减少 在诊断过程中自杀的风险；以及2)测试英杰华测试版在 单组、开放标签试验。正在研究的数字治疗建立在面对面CBT治疗的基础上 方案在临床试验中证明是有效的。成功执行该第一阶段项目的目标将 生产出一种可在临床试验中对病情稳定的患者进行疗效测试的英杰华。在 从长远来看，该项目将通过发展对自杀预防领域产生有益影响 发展移动技术，以促进有效干预措施的提供和传播。

ABSTRACT Suicide is a top ten cause of death in the US and rates of suicide have increased steadily for the last twenty years. Despite this, there is a paucity of research on treatment programs designed to reduce suicide attempts and none that include a digital therapeutic. In this Phase I SBIR application Oui Therapeutics, LLC proposes a project to: 1) create a beta version of the Oui app (called “Aviva”), a CBT-based digital therapeutic to reduce the risk of suicide across diagnoses; and 2) to test the usability and feasibility of the Beta version of Aviva in a single-group, open-label trial. The digital therapeutic being studied is built on face-to-face CBT treatment protocols proven to be effective in clinical trials. Successful execution of the goals of this Phase I project will generate a version of Aviva that is ready to be tested for efficacy with stabilized patients in a clinical trial. In the long term, this project will have a beneficial impact on the field of suicide prevention through the development of mobile technology designed to advance the delivery and dissemination of effective interventions.