Effect of exercise on nocturnal metabolism and sleep quality in individuals with metabolic syndrome

项目摘要 代谢综合征（MetS）在美国非常普遍，与慢性疾病风险增加有关 (e.g.心血管疾病和糖尿病）和睡眠问题。我们的研究团队所做的工作 睡眠不足和夜间脂肪代谢的改变与临床相关的健康状况有关， 结果。运动是一种已知的治疗干预，其可以改善夜间脂肪代谢， 睡眠质量因此，本F32辅导提案的总体目标是确定锻炼的影响 对代谢综合征患者的夜间代谢和睡眠质量的影响。申请人詹妮弗·布兰肯希普博士 我接受了体育活动对24小时血糖控制影响的研究生培训，并建议 人类生物能量学、睡眠和昼夜生理学的额外培训。布兰肯希普博士对 确定运动、睡眠和脂肪代谢之间的联系。布兰肯希普博士和她的指导团队 制定了一个全面的培训计划，将建立在她以前的经验，并扩大她的知识 新领域的技能。布兰肯希普博士的主要培训目标是：（1）提高她的专业水平 通过参加校外和校内会议来发展;（2）获得教学培训 在生物化学和代谢，睡眠和昼夜生理学，和先进的生物统计学;（3）获得经验 在进行机械驱动的人类临床转化研究，通过她提出的研究 项目和与她的导师合作;（4）学习有关睡眠测量的新研究技能 质量，能量代谢和底物氧化;和（5）产生几个第一作者的出版物， 提高她的拨款写作技巧为了实现这些培训目标，布兰肯希普博士提出了一项研究， 研究运动对夜间脂肪和葡萄糖代谢以及睡眠质量的影响， 运动和睡眠之间相互作用的生物学机制。这些初步研究将 在诊断为MetS的成人中进行，因为睡眠问题在该患者人群中很常见， 因为MetS的存在会增加患心血管疾病和糖尿病的风险。成功 这项研究的完成将导致几个第一作者的出版物，以及产生关键的初步 支持竞争性K 01应用程序所需的数据。预计在此培训期间，博士。 布兰肯希普将产生几个共同撰写的出版物有关的正在进行的研究，她的主要 导师的实验室总的来说，这些活动将扩大布兰肯希普博士的知识和技能， 建立一个独立的研究项目，调查身体活动，睡眠， 代谢和慢性疾病风险。F32合同将提供必要的支持和保护时间， 实现这些研究和培训目标。

PROJECT SUMMARY Metabolic syndrome (MetS) is highly prevalent in the US and is associated with increased risk of chronic disease (e.g. cardiovascular disease and diabetes) and sleep problems. Work conducted by our research team has shown that insufficient sleep and alterations in nocturnal fat metabolism are related to clinically relevant health outcomes. Exercise is a known therapeutic intervention which may improve both nocturnal fat metabolism and sleep quality. Therefore, the overall goal of this mentored F32 proposal is to determine the impact of exercise on nocturnal metabolism and sleep quality in individuals with MetS. The applicant, Dr. Jennifer Blankenship, received graduate training in the effects of physical activity on 24-hour glycemic control and is proposing additional training in human bioenergetics, sleep and circadian physiology. Dr. Blankenship is interested in identifying the links between exercise, sleep and fat metabolism. Dr. Blankenship and her mentoring team have developed a comprehensive training plan that will build on her previous experience and expand her knowledge and skills in new areas. Dr. Blankenship’s primary training objectives are to: (1) increase her professional development by attending and participating in extramural and intramural conferences; (2) obtain didactic training in biochemistry and metabolism, sleep and circadian physiology, and advanced biostatistics; (3) gain experience in conducting mechanistically-driven human clinical translational research, through her proposed research project and collaboration with her mentors; (4) learn new research skills pertaining to measurement of sleep quality, energy metabolism, and substrate oxidation; and (5) produce several first-authored publications and enhance her grant writing skills. To achieve these training goals, Dr. Blankenship has proposed a research study to examine the effects of exercise on nocturnal fat and glucose metabolism and sleep quality to better understand the biological mechanisms that drive the interactions between exercise and sleep. These initial studies will be performed in adults diagnosed with MetS because sleep problems are common in this patient population, and because the presence of MetS increases the risk of developing cardiovascular disease and diabetes. Successful completion of this research will result in several first-authored publications as well as generate critical preliminary data needed to support a competitive K01 application. It is expected that during this training period, Dr. Blankenship will generate several co-authored publications related to the ongoing research of her primary mentor’s laboratory. Collectively, these activities will expand Dr. Blankenship’s knowledge and skills necessary to establish an independent research program investigating interactions between physical activity, sleep, metabolism, and chronic disease risk. The F32 award will provide the support and protected time necessary to achieve these research and training objectives.