Admin Core: Identifying genes and Pathways that impact Tau Toxicity in FTD

项目摘要/摘要 这项新的无墙中心(CWow)提案的首要主题是“识别基因和 在FTD中影响tau毒性的途径是发现tau病的新的遗传修饰物，以提供 对疾病机制的独特见解，以及开发和验证一种创新的测量方法 患者使用Tau负荷的血浆样本。核心A将通过提供科学和财政支持来促进这些目标 监督和促进该中心的科学治理战略，以确保 每个核心和项目。核心A将负责管理中心的财务责任，确保 合乎道德和负责任的研究行为，提供科学指导和责任，并报告 向美国国立卫生研究院和公众报告进展情况。为了确保这项研究提案的成功，核心A将 此外，还利用梅奥诊所的资源来促进多学科和跨机构的计划 研究，产生宝贵的生物资源，并促进教育和与该领域的资源共享。 核心A将代表行政管理中心利用梅奥诊所的机构资源 协助赠款管理和人类主题研究的各个方面，以及协调和 利用其他站点的机构资源，包括各种关系和成员资格 项目和核心领导与许多外部组织和财团有密切联系。为了实现这些目标， 核心A将追求以下具体目标。具体目标1：提供行政结构和财政 对Cow的疏忽。具体目标2：承担中心活动的质量控制责任 通过确保负责任的研究进行。具体目标三：推动科学导向、融合发展 通过组织执行指导委员会的定期会议和监督 支持中心核心和项目的外部协作。具体目标4：建立外部 并向美国国立卫生研究院报告进展情况。具体目标5：建立和维持该中心 网站。具体目标6：促进关于FTLD和相关头痛病的教育，并鼓励Cow 调查人员参加病人和照顾者支持小组。

PROJECT SUMMARY/ABSTRACT The overarching theme of this new Center without Walls (CWOW) proposal entitled “Identifying genes and pathways that impact tau toxicity in FTD” is to discover novel genetic modifiers of tauopathy to provide unique insight into disease mechanisms, as well as to develop and validate an innovative approach to measure tau burden in patients using plasma samples. Core A will facilitate these goals by providing scientific and fiscal oversight and promoting the Center's scientific governance strategy to ensure the synergy and integration of each core and project. Core A will be responsible for managing fiscal responsibilities for the Center, ensuring ethical and responsible conduct of research, providing scientific direction and accountability, and reporting progress to the NIH and to the public. In order to ensure the success of this research proposal, Core A will also leverage Mayo Clinic resources to foster a multidisciplinary and cross-institutional program that advances research, generates valuable biological resources, and promotes education and resource sharing with the field. Core A will avail itself of Mayo Clinic institutional resources on behalf of the Center for administrative assistance with grants administration and aspects of human subject research, as well as coordinate and leverage the institutional resources at the other sites, including the various relationships and memberships the project and core leaders have with many external organizations and consortia. To accomplish these goals, Core A will pursue the following specific aims. Specific Aim 1: Provide administrative structure and fiscal oversight for the CWOW. Specific Aim 2: Assume responsibility for the quality control of the Center's activities by ensuring responsible conduct of research. Specific Aim 3: Promote the scientific direction and integration of the Center components by organizing regular Executive Steering Committee meetings and overseeing external collaborations that support the Center cores and projects. Specific Aim 4: Establish an External Advisory Committee and report progress to the NIH. Specific Aim 5: Establish and maintain the Center website. Specific Aim 6: Promote education on FTLD and related tauopathies, and encourage CWOW investigators to participate in patient and caregiver support groups.