Admin Core

弗雷明翰心脏研究-脑老化计划(FHS-BAP)的使命是进行、促进和 推动阿尔茨海默病病因、发病机制、诊断、治疗和预防的高影响力研究 疾病(AD)及相关疾病。行政核心作为组织的着力点 并协调临床、神经心理学和数据核心和项目1-3的研究活动 最大限度地提高协同效应、效率和生产力。在拟议的供资期间，行政核心将指导 丰富的FHS数据资源的延伸和扩展，并建立一个将 极大地提高了世界各地其他研究人员对这一资源的共享和利用。要实现这些目标 作为中心目标，行政核心将作为FHS-BAP内部活动和 外部实体，并确保FHS-BAP活动符合所有核心和项目里程碑，并保持一致 国家老龄研究所(NIA)AD研究任务，并完全符合所有人类受试者的要求， 以及美国国立卫生研究院的科学诚信政策要求。我们会成立一个外间谘询委员会，以 就FHS-BAP优先事项的制定和执行提供建议，并主动发现将 让我们走在前瞻科学的前沿。执行行政核心任务的关键是 对整个FHS-BAP进行适当的财务监督，跟踪所提供材料的处置情况，并 FHS-BAP的成果支持了研究(出版物和资助的活动)，并介绍了#年的进展 达到选管会所述的目标，对评估业务活动的成效至为重要。 在满足研究优先事项及其监督和对改进的持续投入方面帮助确保我们实现 我们宣布的目标。此外，考虑并协调FHS-BAP与其他FHS的日常运作 研究计划(例如，NHLBI资助的FHS合同，以支持FHS队列的核心健康检查)和其他 正在从位于马萨诸塞州弗雷明翰的FHS诊所收集FHS参与者数据的辅助研究将 与内部咨询委员会(IAB)合作完成，该委员会由当地的BU教职员工组成，以更好地 解决时间敏感的后勤问题。行政核心还将促进新的创新广告研究 使用FHS-BAP通过试点项目产生的数据，该项目将鼓励赠款申请 来自初级教员和博士后研究员，以及来自AD领域新手的老牌教员， 整个波士顿大学，可能还有其他机构。促进创新AD研究的额外努力将是 通过促进FHS-BAP调查人员与 地方、国家和国际研究计划，代表FHS-BAP参加科学会议和 通过数据核心宣传FHS-BAP数据的访问和使用，并与BU阿尔茨海默病协调 疾病中心将举办以AD研究为重点的研讨会和座谈会。

The mission of the Framingham Heart Study–Brain Aging Program (FHS-BAP) is to conduct, facilitate and promote high impact research on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer disease (AD) and related disorders. The Administrative Core serves as a focal organizational point to organize and harmonize research activities of the Clinical, Neuropsychology, and Data Cores and Projects 1-3 to maximize synergy, efficiency and productivity. In the proposed funding period, the Administrative Core will guide the extension and expansion of the rich FHS data resource and establish a management infrastructure that will greatly increase the sharing and utilization of this resource by other researchers worldwide. To accomplish these central goals, the Administrative Core will serve as the interface between internal FHS-BAP activities and external entities, and ensure that FHS-BAP activities meet all Core and project milestones and are consistent with the National Institute of Aging (NIA) AD research mission and in full compliance with all human subjects, and scientific integrity policy requirements of the NIH. We will form an External Advisory Committee (EAC) to advise on the formulation and execution of FHS-BAP priorities and proactively identify opportunities that will keep us on the forefront of forward-thinking science. Key to executing the Administrative Core's mission is to provide appropriate financial oversight of the entire FHS-BAP, track the disposition of materials provided and the outcomes of FHS-BAP supported research (publications and funded activities) and present progress in meeting the stated aims to the EAC feedback will be critical in assessing effectiveness of operational activities in meeting research priorities and their oversight and continuous input for improvements help ensure we achieve our stated goals. Additionally, consideration and coordination of FHS-BAP day-to-day operations with other FHS research programs (e.g., NHLBI funded FHS contract to support core health exams of FHS cohorts) and other ancillary studies that are collecting data from FHS participants at the FHS clinic based in Framingham, MA will be done in collaboration with an Internal Advisory Board (IAB), consisting of locally based BU faculty to better address time-sensitive logistical issues. The Administrative Core will also promote new innovative AD research using data generated by the FHS-BAP through a pilot project program that will encourage grant applications from junior faculty and postdoctoral fellows, as well as from established faculty who are new to the AD field, throughout BU and possibly other institutions. Additional efforts to foster innovative AD research will be facilitating cross-core/project interactions by promotion of collaborations between FHS-BAP investigators with local, national, and international research programs, by representing the FHS-BAP at scientific meetings and publicizing FHS-BAP data access and use through the Data Core and coordinating with the BU Alzheimer Disease Center to host seminars and symposia focused on AD research.