Investigating the relationship between menthol flavor and nicotine metabolism in African Americans who smoke cigarettes

项目摘要 非洲裔美国人比白人更有可能死于与吸烟相关的疾病，而在 使用目前FDA批准的辅助设备戒烟。因此，这项提案旨在调查电子-- 香烟对非裔美国人和白人吸烟者减少吸烟的影响。这项建议将澄清 电子烟中尼古丁代谢和尼古丁浓度与吸烟行为的关系 非裔美国人和白人吸烟者的毒物暴露。我们假设缓慢的尼古丁代谢物会 在所有尼古丁浓度下，尼古丁血浆水平高于正常尼古丁代谢物，并报告 更大的积极主观效果。此外，我们假设缓慢的尼古丁代谢物将比 可能通过电子烟减少吸烟，因为研究表明吸烟者尼古丁代谢较慢 在尼古丁替代疗法上比正常或快速尼古丁代谢的吸烟者更成功。这个 该项目的成果将提供新的信息，以进一步发展了解方面的知识库 制造商应该在电子液体中包括哪些尼古丁浓度，以减少吸烟行为。 监管措施可以限制电子烟中的尼古丁含量，以降低电子烟使人上瘾的可能性 但为吸烟者，特别是非裔美国吸烟者提供了一个减少伤害的途径来保护 整体公共卫生。

Project Summary African Americans are more likely than Whites to die from smoking related diseases and are less successful at smoking cessation with the current FDA-approved aids. Thus, this proposal seeks to investigate the use of e- cigarettes on smoking reduction in African American and White smokers. This proposal will elucidate the relationship between nicotine metabolism and nicotine concentrations in e-cigarettes on smoking behavior and toxicant exposure in African American and White smokers. We hypothesize that slow nicotine metabolizers will have higher nicotine plasma levels than normal nicotine metabolizers at all nicotine concentrations and report greater positive subjective effects. Additionally, we hypothesize that slow nicotine metabolizers will be more likely to reduce their smoking with e-cigarettes because studies show slower nicotine metabolizing smokers are more successful on nicotine replacement therapies than normal or fast nicotine metabolizing smokers. The outcomes of the project will provide new information to further develop the knowledge base in understanding which nicotine concentration manufacturers should include in e-liquids to reduce smoking behaviors. Regulatory efforts could cap the nicotine content in e-liquids to reduce the addictive potential of e-cigs to adolescents but provide a harm reduction avenue for smokers, especially African American smokers, to protect overall public health.