Program 35: Melanoma

黑色素瘤计划 项目摘要/摘要 黑色素瘤计划的临床前和临床研究人员推进了该计划的使命，以研究所有 黑色素瘤的各个方面，并将发现转化为可操作的诊断、预防和治疗 这些机会将改善患者的生活，并有助于我们对疾病的了解。这个 该计划的具体目标是：1)了解黑色素瘤的分子发病机制，包括 基因组学、表观基因组学、代谢组学，并利用这些信息进行最佳治疗靶向；2) 了解肿瘤-宿主的相互作用，并利用这些信息来优化针对 肿瘤微环境；3)了解调节黑色素瘤的外部环境因素 风险和致癌，以及与黑色素瘤形成相关的人类行为。该计划 有44名成员，代表6个DF/CC机构和7个学术部门。2014年的同行- 经审查的赠款资金归因于该方案，总费用为370万美元，来自NCI的160万美元 来自其他赞助商。在目前的资助期间，黑色素瘤计划成员发表了873种癌症- 相关文件。其中30%是机构间的，21%是方案内的，39%是机构间的 两个或多个DF/HCC成员之间的程序性协作。总体而言，如果算一次，27%的 DF/CC出版物是方案间的协作。

Melanoma Program Project Summary / Abstract Preclinical and clinical researchers in the Melanoma Program advance the Program mission to study all aspects of melanoma and translate the findings into actionable diagnostic, preventative, and therapeutic opportunities that will improve the lives of patients and contribute to our understanding of the disease. The Specific Aims of the Program are: 1) To understand the molecular pathogenesis of melanoma, including genomics, epigenomics, metabolomics, and utilize this information for optimal therapeutic targeting; 2) To understand tumor-host interactions and utilize this information to optimize therapeutic strategies that target the tumor microenvironment; and 3) To understand the external environmental factors that modulate melanoma risk and carcinogenesis, as well as the human behaviors associated with melanoma formation. The program has 44 members, representing six DF/HCC institutions and seven academic departments. In 2014 peer- reviewed grant funding attributed to the Program was $3.7 million in total costs from the NCI and $1.6 million from other sponsors. During the current funding period, Melanoma Program members published 873 cancer- relevant papers. Of these 30% were inter-institutional, 21% were intra-programmatic, and 39% were inter- programmatic collaborations between two or more DF/HCC members. Overall, when counted once, 27% of DF/HCC publications were inter-programmatic collaborations.