Inadequate Cardiovascular and Thermoregulatory Responses in the Elderly during Heat Waves

项目总结 热浪是最致命的自然灾害，对老年人的健康造成不成比例的影响。这 老年人死亡率和发病率的增加主要源于心血管疾病。然而，我们目前 对老年人对热应激心血管反应的了解仅限于非生理性 模特们。因此，这项工作的总体目标是确定心血管疾病增加的标志物 和热浪样条件下老年人的体温调节应激。目标1将评估 老年人对热浪条件的心血管反应。具体地说，我们假设老年人 年龄在65岁以上的参与者将在模拟高温中表现出心血管反应受损 与更年轻的成年人相比，海浪状况。我们将全面评估心血管和体温 老年参与者和年轻人在高温和潮湿两种热浪条件下的反应 (复制1995年芝加哥热浪)，炎热干燥(复制2018年洛杉矶热浪)。目标2将 确定对热浪条件下心血管和体温调节反应差的预测因子 老年人。我们预计静息状态下心血管功能的个体间差异可以用来预测 老年参与者对模拟热浪条件的体温调节和心血管反应较差。 使用探索性预测建模方法分析来自目标1的数据，我们将确定基线 以及预测老年人对热应激反应不佳的人口统计因素。的预期结果 这项工作将建立关于心血管和体温调节后果的基础知识 老年人的热浪，可以用来针对未来的战略和治疗，以帮助降低健康 给这一弱势群体带来的风险。

PROJECT SUMMARY Heat waves are the deadliest natural disaster and disproportionately affect the health of the elderly. This increased mortality and morbidity in the elderly is primarily cardiovascular in origin. However, our current understanding of the cardiovascular responses of the elderly to heat stress is limited to non-physiological models. Therefore, the overall objective of this work is to identify markers of increased cardiovascular and thermoregulatory stress during heat wave-like conditions in the elderly. Aim 1 will assess the cardiovascular responses of the elderly to heat wave conditions. Specifically, we hypothesize that elderly participants, aged older than 65, will demonstrate impaired cardiovascular responses during simulated heat wave conditions compared to younger adults. We will comprehensively assess the cardiovascular and thermal responses of elderly participants and younger adults exposed to two heat wave conditions, hot and humid (replicating the 1995 Chicago heat wave), hot and dry (replicating the 2018 Los Angeles heat wave). Aim 2 will determine predictors of poor cardiovascular and thermoregulatory responses to heat wave conditions in the elderly. We anticipate that inter-individual variations in resting cardiovascular function can be used to predict poor thermoregulatory and cardiovascular responses to simulated heat wave conditions in elderly participants. Using an exploratory predictive modeling approach to analyze the data from Aim 1, we will identify baseline and demographic factors that predict poor responses to heat stress in the elderly. The expected outcomes of this work will establish foundational knowledge of the cardiovascular and thermoregulatory consequences of heat waves for the elderly, that can be used to target future strategies and therapies to help reduce the health risks to this vulnerable population.