Psychomotor and cognitive development problems in a cohort of children after respiratory infection during pregnancy and/or early childhood

摘要 以前的一项研究题为流感发病率，诊断，治疗效果，疫苗 有效性（INFLUMI-奖项：1U 01 IP 000791 -01），在2013年之间进行 和2018年在巴拿马和萨尔瓦多，观察到呼吸道病毒的影响，主要是 流感对一组妇女（N=2565）及其子女（N=1586）的影响。因此，要求 强大的流行病学、临床和实验室监测系统和研究 基础设施演进作为孩子们评估的一部分， （N=1088），以确定任何认知，心理或语言障碍。本 该项目建议改善监测、报告和流行病学情报， 对儿童队列进行进一步随访，直至8岁。的首要目标 拟议的项目是进一步评估精神疾病、认知疾病和 行为发展问题的儿童在队列中。在拟议的 2019年11月，孩子们将年满3.5岁。我们假装跟随他们 四年了。这将通过建立现有的伙伴关系和以前的 研究;支持哨兵监测的发展、维持和扩大 在巴拿马和萨尔瓦多的研究地点，并通过评估对神经认知发育的影响， 怀孕期间频繁和严重的呼吸道感染可能会影响早期 童年过程包括在治疗期间与儿童接触和重新进入系统。 第一年随后几年将包括流感、流感的培训和能力建设 预防和美洲其他呼吸道病原体监测。

Abstract A previous study titled Influenza Incidence, Diagnosis, Treatment Efficacy, Vaccine Effectiveness (INFLUMI-Award: 1U01IP000791-01), which was conducted between 2013 and 2018 in Panama and El Salvador, observed the impact of respiratory virus, mainly influenza on a cohort of women (N=2565) and their children (N=1586). Thus, requiring robust epidemiologic, clinical, and laboratory surveillance systems and research infrastructure. As part of the children's evaluation, a Bayley's III test was conducted (N=1088) to determine any cognitive, psychomotor, or language impairment. The present project proposes to improve surveillance, reporting and epidemiological intelligence with further follow-up of the children cohort up to eight (8) years of age. The overarching goal of the proposed project is to further evaluate the prevalence of psychomotor, cognitive, and behavioral development problems among children in the cohort. At start of the proposed Project in November 2019, the children will be 3.5 years of age. We pretend to follow them up for four years. This will be accomplished by building-on existing partnerships and previous research; supporting the development, maintenance, and expansion of sentinel surveillance sites in Panama and El Salvador and by evaluating the effect on neurocognitive development of frequent and severe respiratory infections during pregnancy that might impact early chilhood. Processes include contact of children and re-introduction into the system during the first year. Subsequent years will include training and capacity building of influenza, influenza preparedness, and other respiratory pathogen surveillance in the Americas.