Advancing Child Health Through Cellular and Molecular Biology

项目总结/摘要 密歇根大学儿童健康研究职业发展奖（CHRCDA）计划是 旨在支持初级儿科研究人员的职业发展。CHRCDA学者参加 在细胞和分子生物学以及教学教育密集，指导培训计划 该计划旨在确保其持续的研究开发。自1992年推出以来， CHRCDA为培训近50名儿科医生-科学家做出了贡献，其中大多数人 获得了美国国立卫生研究院的R级资金，用于儿童疾病的研究。本续期申请的目的是： 1)招募最有前途的初级儿科医生-科学家进行培训，包括来自 不同的背景为了扩大我们的儿科医生科学家的范围，范围和多样性， “管道”，我们现在计划与密歇根州儿童医院进行区域合作， 底特律韦恩州立大学医学院的附属机构。 2)加强儿科医生-科学家的转化研究培训。对于学者来说， 参与转化研究团队，汇集医生，实验室科学家，统计学家，专利 专家，更多。为了实现这一目标，我们计划利用密歇根研究所的资源， 临床和健康研究（MICHR，密歇根大学CTSA的所在地），以及 3)认识到许多儿科疾病在服务不足的人群中更为常见， 部分来自饮食和环境暴露。儿童肥胖与铅和其他物质的接触 环境毒素是导致密歇根州儿童疾病的重要因素。为了满足这一需求，我们 计划进一步扩大我们的导师基地从密歇根大学儿科系到其他 部门和学校，包括密歇根大学公共卫生学院和韦恩州 环境健康科学大学研究所。 为了实现这些目标，项目主任Opipari博士和联合培训主任Hershenson博士 和利普舒尔茨，将由1）科学咨询委员会协助，以监督项目方向和学者 选择和评估; 2）外部咨询委员会，对计划进行独立审查; 3） 一个教育中心，负责监督学者的教学培训; 4）两名招聘干事，协助确定 和少数民族候选人的招聘;和5）国家计划审查谁将被邀请到校园， 对该计划进行年度审查，并评估UM CHRCDA学者的进展情况。 最后，由于迫切需要培训儿科医生-科学家，密歇根大学医学院 院长办公室和儿科和传染病系已同意提供匹配 在五年的奖学金期限内，每年增加一名奖学金获得者。

Project Summary / Abstract The University of Michigan Child Health Research Career Development Award (CHRCDA) program is designed to support the career development of junior pediatric investigators. CHRCDA scholars participate in an intensive, mentored training program in cell and molecular biology as well as a didactic educational program designed to ensure their continued research development. Since its launch in 1992, the Michigan CHRCDA has contributed to the training of nearly 50 pediatrician-scientists, the majority of whom have obtained R-level NIH funding for the study of childhood diseases. The Aims of this renewal application are to: 1) Recruit the most promising junior pediatrician-scientists for training, including those from diverse backgrounds. In order to broaden the scope, reach and diversity of our pediatrician-scientist “pipeline,” we now plan to undertake a regional collaboration with the Children's Hospital of Michigan, an affiliate of Wayne State University School of Medicine in Detroit. 2) Enhance the translational research training of pediatrician-scientists. It is essential for scholars to participate in translational research teams bringing together physicians, bench scientists, statisticians, patent experts, and more. To accomplish this goal, we plan to leverage the resources of the Michigan Institute for Clinical and Health Research (MICHR, home of the University of Michigan CTSA), and 3) Recognize that many pediatric diseases are more common in underserved populations and arise in part from dietary and environmental exposures. Childhood obesity and exposure to lead and other environmental toxins are important contributors to disease in Michigan children. To address this need, we plan to further extend our mentor base from the University of Michigan Department of Pediatrics to other Departments and Schools, including the University of Michigan School of Public Health and the Wayne State University Institute of Environmental Health Sciences. To achieve these Aims, the Program Director, Dr. Opipari, and Co-Training Directors, Drs. Hershenson and Lipshultz, will be assisted by 1) a Scientific Advisory Committee to oversee program direction and scholar selection and evaluation; 2) an External Advisory Board to provide an independent review of the program; 3) an Education Core to oversee scholar didactic training; 4) two Recruitment Officers to assist in identification and recruitment of minority candidates; and 5) National Program Reviewers who will be invited to campus to perform an annual review of the program and assess the progress of the UM CHRCDA Scholars. Finally, due to the urgent need to train pediatrician-scientists, the University of Michigan Medical School Dean's Office and the Department of Pediatrics and Communicable Diseases has agreed to supply matching funds for one additional Scholar per year for the five-year term of the award.