The interactive effects of physical activity and sedentary behaviors during childhood on adiposity in early adulthood

项目摘要 2018年体力活动指南科学报告总结了最新的证据， 这表明，对于年轻人来说，体育锻炼对预防肥胖的效果的证据是强有力的，但 久坐行为影响的证据仍然有限。该报告确认了几个重要的 知识差距，其中之一是关于体育活动的独立和互动影响以及 久坐行为对健康结果的影响。各国体力活动指南的突然不同 从青年到成年的过渡阶段(例如，青年每天一小时，成年人每周2.5小时)也是 公认是有问题的。为了解决这些差距，我们建议进行汇集分析，以量化 体力活动和久坐行为对成年早期肥胖的独立和交互影响。 主要的假设是：(1)儿童和成年早期的健康体力活动模式是 与成年早期的低肥胖率有关，与久坐行为无关，以及(2)更健康 久坐不动的行为模式只与成年早期肥胖程度较低的人有关 健康的体力活动模式。这项研究的第一个目的是检查不同的轨迹模式 11至24岁的中等强度和高强度的体力活动和久坐行为，使用 基于群体的双轨迹分析方法。第二个目标是比较22-24岁年龄段的肥胖率 中等强度和高强度的身体活动和久坐行为轨迹模式。两个子目标 是：检查更健康的体力活动和/或久坐的行为模式是否与 儿童早期肥胖儿童在22-24岁时肥胖风险较低；并检查剂量- 中等强度和大强度体力活动与久坐行为与脂肪的反应关系 青年到成人过渡期(从15-17岁到22-24岁)的质量变化。为了实现这些目标， 我们将使用三项出生队列研究的汇集数据：英国雅芳父母和孩子纵向研究， 巴西1993年的佩洛塔斯研究和美国爱荷华州的骨发育研究。汇集的数据将使我们能够 样本多样，有足够的力量进行亚群分析。这个低成本的独立R03项目是 希望通过解决这些知识来产生新的知识来更新体力活动指南 差距。

Project Summary The 2018 Physical Activity Guidelines Scientific Report, which summarized the most up-to-date evidence, suggested that, for youth the evidence for the effects of physical activity on obesity prevention is strong but the evidence for the effects of sedentary behavior remains limited. The report recognizes several important knowledge gaps, one of which is regarding the independent and interactive effects of physical activity and sedentary behavior on health outcomes. The abrupt difference in the physical activity guidelines across the transitional stage from youth to adulthood (e.g., daily one hour for youth vs. weekly 2.5 hours for adults) is also recognized as problematic. To address these gaps, we propose to conduct a pooled analysis to quantify the independent and interactive effects of physical activity and sedentary behavior on adiposity in early adulthood. The main hypotheses are (1) a healthier physical activity pattern during childhood and early adulthood is associated with lower adiposity in early adulthood, independent of sedentary behavior, and (2) a healthier sedentary behavior pattern is associated with lower adiposity in early adulthood only among those with a less healthy physical activity pattern. The first aim of this study is to examine the diverse trajectory patterns of moderate- and vigorous-intensity physical activity and sedentary behavior from age 11 to 24 years, using a group-based dual trajectory analysis approach. The second aim is to compare adiposity at age 22-24 years by moderate- and vigorous-intensity physical activity and sedentary behavior trajectory patterns. Two sub-aims are: to examine whether healthier physical activity and/or sedentary behavior patterns are associated with a lower risk of obesity at age 22-24 years among children with early childhood obesity; and to examine a dose- response relationship of moderate- and vigorous-intensity physical activity and sedentary behavior with fat mass change in the youth to adult transition period (from age 15-17 to 22-24 years). To achieve these aims, we will use pooled data from three birth cohort studies: U.K. Avon Longitudinal Study of Parents and Children, Brazil 1993 Pelotas Study, and U.S. Iowa Bone Development Study. The pooled data will enable us to have a diverse sample and sufficient power for the subgroup analysis. This low-cost self-contained R03 project is expected to produce new knowledge to update the Physical Activity Guidelines by addressing these knowledge gaps.