New strategies for enhancing chimeric antigen receptor (CAR) T cell therapy for cancer

免疫系统在癌症中的作用现在被认为是非常重要的，患者免疫治疗的成功突显了这一点。然而，由于肿瘤部位淋巴细胞的频率较低，许多患者对这种治疗形式没有反应。一种涉及基因修饰淋巴细胞转移的新形式的免疫治疗是克服这一问题的潜在方法。该项目将探索新的战略，以加强这一方法对血液和固体癌症的效用。

The role of the immune system in cancer is now recognised as highly important, highlighted by the success of immunotherapy in patients. Yet many patients fail to respond to this form of treatment due to low frequency of lymphocytes present at the tumor site. A new form of immunotherapy involving transfer of gene-modified lymphocytes is a potential way to overcome this problem. This project will explore new strategies to enhance the utility of this approach against blood and solid cancers.