New strategies for enhancing chimeric antigen receptor (CAR) T cell therapy for cancer

免疫系统在癌症中的作用现在被认为是非常重要的，免疫治疗在患者中的成功突出了这一点。然而，由于肿瘤部位存在的淋巴细胞频率低，许多患者对这种形式的治疗没有反应。一种新形式的免疫疗法，包括基因修饰的淋巴细胞的转移是一个潜在的方法来克服这个问题。该项目将探索新的策略，以提高这种方法对血液和固体癌症的效用。

The role of the immune system in cancer is now recognised as highly important, highlighted by the success of immunotherapy in patients. Yet many patients fail to respond to this form of treatment due to low frequency of lymphocytes present at the tumor site. A new form of immunotherapy involving transfer of gene-modified lymphocytes is a potential way to overcome this problem. This project will explore new strategies to enhance the utility of this approach against blood and solid cancers.