Diversity supplement for Oliver Viyar to receive research training in tissue engineering.

总结/摘要 这一补充是根据家长赠款提交“地图：一个可流动的，精确的工程，和可调的 利用超多孔几何结构控制炎症并促进再生愈合的组织支架 糖尿病伤口”是给奥利弗维亚的，他将作为一名菲律宾裔美国人， 少数民族的申请。Viyar先生是一名学士后研究员，他对以下方面表现出兴趣： 并希望在申请研究生院入学的同时进行健康相关科学的研究培训。 先生Voyar希望参加生物医学工程博士课程，最终目标是追求他的 作为生物技术行业的首席科学家。他在申请之前寻求额外的研究培训 申请博士学位Viyar先生于2019年5月获得化学专业理学学士学位。 弗吉尼亚大学的工程学教授。毕业后，Viyar先生开始担任研究助理 在克里思治疗公司 母基金的总体目标是继续开发微孔退火颗粒 (MAP)用于治疗受损的糖尿病足溃疡（DFU）的生物材料技术。我们的MAP材料是 可流动（易于应用）并填充多种形状和尺寸的伤口， 暴露于LED白色光后，伤口部位出现海绵状网络。超孔隙度几何学 促进快速组织向内生长、早期血管化和更快的伤口再上皮化， 导致脱细胞组织基质，炎症反应最小。我们雇用 糖尿病猪伤口愈合受损的专门模型，以测试一套三种制剂变体 已经在初步的健康猪研究中得到证实。MAP的最佳配方， 缓慢愈合环境和刺激组织再生将被选择用于安全性分析， 将在提案结束时提交试验用器械豁免（IDE）。 在这一补充和关于这一家长补助金，Viyar先生将直接在Deshayes博士的领导下工作。 监督的主要目标是优化制造过程的一个步骤， 组成MAP产品的水凝胶微球。目前的制造工艺面临一些 可扩展性和无菌性的挑战。因此，Viyar先生将研究使用静态混合方法 而不是机械搅拌方法来制造水凝胶微球以增强 生产规模和简化无菌过程。德沙耶斯博士将为他提供研究指导 和职业指导。此外，Viyar先生将接受大型动物临床前研究， 监管过程。

SUMMARY / ABSTRACT This supplement is submitted under the parent grant “MAP: a flowable, precision-engineered, and tunable tissue scaffold leveraging hyper-porous geometry to control inflammation and promote regenerative healing in diabetic wounds” and is for Oliver Viyar B.S., who will be the diversity investigator as a Filipino American minority on the application. Mr. Viyar is a post-baccalaureate researcher, who has demonstrated an interest in and wish to pursue research training in health-related sciences while applying for admission to graduate school. Mr. Voyar wishes to enroll in a PhD program for biomedical engineering with the ultimate goal to pursue his career as a lead scientist in the biotechnology industry. He seeks additional research training prior to applying for admission to PhD programs. Mr. Viyar received his Bachelor of Science degree in May 2019 in Chemical Engineering at the University of Virginia. After his graduation, Mr. Viyar began working as a research assistant at Tempo Therapeutics, Inc. The overall goal of the parent grant is to continue the development of the Microporous Annealed Particle (MAP) biomaterial technology for the treatment of impaired diabetic foot ulcers (DFUs). Our MAP materials are flowable (ease of application) and fill wounds of multiple shapes and sizes and convert to a hyper-porous sponge-like network in the wound site after exposure to LED white light. The hyper-porosity geometry promotes fast tissue ingrowth, early vascularization, and faster wound re-epithelialization when compared to leading decellularized tissue-based matrices, with minimal inflammatory response. We are employing specialized models of impaired wound healing in diabetic pigs to test a suite of three formulation variants already demonstrated in a preliminary healthy swine study. The optimal formulation of MAP that performs in slow healing environments and stimulates tissue regeneration will be selected for safety profiling and an Investigational Device Exemption (IDE) will be submitted at the end of the proposal. In this supplement and in regard to this parent grant, Mr. Viyar will be working directly under Dr. Deshayes’ supervision with the main goal to optimize one step of the manufacturing process for the fabrication of the hydrogel microspheres that compose the MAP product. The current manufacturing process faces some challenges of scalability and sterility. Therefore, Mr. Viyar will investigate the use of a static mixing method rather than a mechanical stirring method to fabricate the hydrogel microspheres in order to enhance the production scale and ease the aseptic process. Dr. Deshayes will provide him with both research mentorship and career guidance. In addition, Mr. Viyar will receive exposure to pre-clinical studies on large animals and regulatory process.