Cell Biology Program

细胞生物学计划项目总结 癌症通常被称为一种“细胞生物学问题”，指的是遗传或环境异常 损伤导致基因调控、细胞分裂、细胞黏附等基本细胞功能发生深刻变化， 受体信号和运输，以及分化。梅奥诊所癌症中心的中心目标 (MCCC)细胞生物学计划是定义肿瘤转化的分子遗传和细胞基础， 生长和转移，同时提供对细胞生长和衰老、器官发育、 染色质动力学和基因组改变。MCCC细胞生物学计划包括来自16个国家的34个成员 共同带来大量NIH癌症资金的不同部门(450万美元直接用于56%) 来自NCI)。这些成员对广泛的癌症进行研究，主要集中在4个领域 具体目标：1)研究调节细胞周期的基本遗传和表观遗传机制 在正常、衰老和肿瘤细胞中的转录调控；2)通过 哪些细胞信号通路和受体内吞活性促进不受控制的细胞生长；3) 确定癌细胞及其微环境之间的串扰如何通过以下方式促进癌症生长 调节新生血管生成、炎症、免疫逃避和纤维化；以及4)了解细胞如何 附着到底物和彼此，以及这些附着是如何在细胞启动迁移和 入侵。细胞生物学项目研究与疾病的发生或预防有关的细胞过程。 广泛的人类癌症，并与其他MCCC计划广泛对接。除了……之外 进行创新和前沿的癌症相关研究，细胞生物学计划组织和 赞助许多互动式科学会议，包括国家和国际会议，并提供 梅奥诊所基础癌症生物学中心。在我们发表的483篇与癌症有关的论文中 2013至2017年间，66名成员是方案内成员，235名成员是方案间成员，强调 该计划为癌症中心带来的高附加值。

CELL BIOLOGY PROGRAM PROJECT SUMMARY Cancer is commonly referred to as a “cell biological problem” in which genetic abnormalities or environmental insults induce profound changes in basic cellular functions such as gene regulation, cell division, cell adhesion, receptor signaling and trafficking, and differentiation. The central goal of the Mayo Clinic Cancer Center (MCCC) Cell Biology Program is to define the molecular genetic and cellular basis of neoplastic transformation, growth, and metastasis while providing insights into cell growth and senescence, organ development, chromatin dynamics, and genomic alterations. The MCCC Cell Biology Program includes 34 members from 16 different departments that collectively bring in substantial cancer-based NIH funding ($4.5M directs with 56% from the NCI). These members conduct research across a broad spectrum of cancers, which is focused in 4 specific aims: 1) To investigate the fundamental genetic and epigenetic mechanisms regulating the cell cycle and transcription control in normal, senescent, and neoplastic cells; 2) To elucidate the mechanisms through which cell signaling pathways and receptor endocytic activity promote uncontrolled cell growth; 3) To determine how the crosstalk between cancer cells and their microenvironment promotes cancer growth by regulating neo-angiogenesis, inflammation, immune evasion, and fibrosis; and 4) To understand how cells attach to substrates and to each other, and how these attachments are altered as a cell initiates migration and invasion. The Cell Biology Program studies cellular processes relevant to the development or prevention of a broad spectrum of human cancers and broadly interfaces with other MCCC Programs. In addition to conducting innovative and cutting-edge cancer-relevant research, the Cell Biology Program organizes and sponsors many interactive scientific gatherings, including national and international meetings, and provides a central hub for basic cancer biology at Mayo Clinic. Of the 483 cancer-relevant papers published by our members between 2013 and 2017, 66 were intraprogrammatic and 235 were interprogrammatic, underscoring the high value added by the Program to the Cancer Center.