Research Core Methods

项目总结研究方法核心C 核心方法将提供统计分析技术、研究设计、心理设计等服务和培训 健康(MH)测量和数据管理。与迈阿密大学发展性艾滋病 UM D-ARC研究中心(UM D-ARC)S强调减少心理健康和少数民族健康的影响 在艾滋病毒预防和护理连续阶段的差异我们专注于多层次的方法。MH co- 病态本质上是个体层面的过程。相比之下，MH和少数族裔的健康差距是 通过存在于不同级别的更高级别的结构性社会文化进程(如社区、城市、 区域)，个体嵌套在其中。因此，中心调查人员的干预和方法 它可能既涉及个人，也涉及这些社会文化进程，因此是多层次的。 核心方法有三个目标。目标1：促进使用适当的最新科学技术 多层次研究中的研究设计和统计方法，将为当地实施 循证实践符合UM D-ARC的主题和目标。为实现这一目标而开展的活动 将包括向艾滋病毒/艾滋病MH研究人员提供咨询，制定NIH赠款提案(以及 获奖后支持)并在研究领域通过UM-ARC试点研究向早期调查员提供支持 设计、使用艾滋病毒及其共病的生物标志物，以及统计分析战略。目标2：创造， 维护并促进使用中央数据储存库和仪表库作为以下资源 关于MH和艾滋病毒/艾滋病中少数群体健康差异的高影响研究。这将包括一项自愿 统一数据架构，包括通用数据元素，以促进协作和协作 以创新的新方式利用D-ARC数据的项目和包括西班牙语和 海地克里奥尔语措施。我们将提供查阅现有电子数据收集表格和 关于如何为新措施创建新的电子数据收集表格的说明。目标3：提供 对其他UM D-ARC核心资源的分类访问以及最新的科学方法 补充和扩大现有UM资源的讲习班和其他能力建设活动 重点关注MH在艾滋病毒/艾滋病方面的差异。支持这一目标的活动包括创建一个全面的 研究导航平台，协调访问D-ARC方法咨询和All中心 资源；举办以新方法为重点的研讨会，内容包括多层次建模、地理信息系统制图 关于MH结果、确定亚组和估计治疗效果异质性的方法、途径 到实施研究，以及模式选择方法。该核心还将促进协商和 来自其他D-ARC核心和附属研究小组的演讲，如CFAR、CTSI、NIDA的 国家药物滥用治疗临床试验网络，以及NIDA的P30珍爱中心，专注于 成本效益分析。

Project Summary Research Methods Core C The Methods Core will provide services and training in statistical analysis techniques, research design, mental health (MH) measurement, and data management. With the University of Miami Developmental AIDS Research Center (UM D-ARC)’s emphasis on Reducing the Impact of Mental Health and Minority Health Disparities across the HIV Prevention and Care Continua we focus on multi-level methods. MH co- morbidities are inherently individual-level processes. In contrast, MH and minority health disparities are driven by higher-level structural socio-cultural processes that exist at the various levels (e.g. neighborhoods, cities, regions) within which the individual is nested. Therefore, interventions and approaches of center investigators are likely to address both individuals as well as these socio-cultural processes and, thus, be multi-level. The Methods Core has three aims. Aim 1: To promote use of appropriate state-of-the-science research design and statistical methods in multi-level research that will inform local implementation of evidence-based practice consistent with the UM D-ARC theme and goals. Activities to address this aim will include providing consultation to HIV/AIDS MH researchers developing NIH grant proposals (as well as post-award support) and supporting early stage investigator with UM-ARC pilot studies in the areas of research design, use of biomarkers of HIV and its comorbidities, and statistical analysis strategies. Aim 2: To create, maintain, and facilitate use of a centralized data repository and an instrument library as resources for high-impact research on MH and minority health disparities in HIV/AIDS. This will include a voluntary unified data architecture that includes common data elements to facilitate collaboration and cooperative projects to utilize D-ARC data in innovative new ways and a REDCap instrument library including Spanish and Haitian Creole-language measures. We will provide access to existing electronic data collection forms and instruction on how to create new electronic data collection forms for new measures. Aim 3: To provide triaged access to other UM D-ARC Core resources as well as state-of-the science methodology workshops and other capacity-building activities that complement and expand existing UM resources to focus on MH disparities in HIV/AIDS. Activities to support this aim include creation of a comprehensive Research Navigation Platform to coordinate access to D-ARC methodology consultations and all Center resources; and conducting new methods-focused workshops with content on multilevel modeling, GIS mapping of MH outcomes, methods for identifying subgroups and estimating treatment effect heterogeneity, approaches to implementation research, and model selection approaches. The Core will also facilitate consultations and presentations from other D-ARC cores and affiliated research groups, such as the CFAR, CTSI, NIDA’s National Drug Abuse Treatment Clinical Trials Network, and NIDA’s P30 CHERISH Center, which focuses on cost-effectiveness analysis.