Global Infectious Diseases and HPV Research Training in Kenya

摘要 人类乳头瘤病毒(HPV)是世界上最常见的性传播感染，85%的 感染发生在中低收入国家(LMIC)。几乎所有的宫颈癌都是由 持续的HPV感染，87%的宫颈癌死亡发生在LMIC。检测、预防和 因此，治疗HPV感染是该国和该区域的主要卫生优先事项。阿加汗大学东区 非洲大学(AKU)是一所首屈一指的医疗和护理学术机构，其独特的定位是解决全球传染病 疾病和人乳头瘤病毒。它是一所成长中的大学，在肯尼亚、乌干达和坦桑尼亚设有校区，它已经发起了 为东非医生设立的首个临床传染病(ID)奖学金。然而，为了实现 AKU的目标是成为一流的研究机构，需要进一步的研究能力建设和支持来培养 AKU拥有深厚科学专业知识的卫生研究人员的关键群体。这项提议的目标是 为了：1)增加对HPV感染及其影响的预防、检测和治疗的研究 癌症；2)加强AKU进行传染病研究的能力；3)扩大 东非AKU校区的临床研究知识和技能。拟议的研究 培训计划将由Marleen Temmerman博士和Michael Chung博士领导，他们将是多个计划 董事们。他们将与华盛顿大学(UW)及其广泛的 在肯尼亚成功实施研究培训计划。威斯康星大学已经培训了数百名肯尼亚人 30多年的健康研究。威斯康星大学还拥有一个由教职员工领导的世界知名的HPV研究小组 来自威斯康星大学和弗雷德·哈钦森癌症研究中心的专家。Temmerman博士和Chung Will博士 为肯尼亚人建立一个为期不同的三个轨道的联合研究培训计划。长期的 Track将允许AKU ID研究员通过参加以下课程获得UW公共卫生硕士(MPH)学位 西雅图，并在肯尼亚进行实地考察；中期轨道将邀请AKU医疗和护理 教职研究人员在威斯康星大学学习了3个月的课程，然后在肯尼亚进行了一个指导项目；以及 短期课程将为整个东非的AKU教职员工和学生提供一个机会 通过肯尼亚内罗毕的面对面研讨会学习助学金和手稿写作以及领导技能 以及威斯康星州大学的在线课程。共有3名AKU ID研究员将在密歇根大学获得公共卫生硕士学位，10名AKU教职员工 成员将在华盛顿大学接受非学位课程，数百名实习生将参加研讨会和 在线课程。毕业后，ID研究员将被提供AKU的学术医学职位并加入教职 以及在AKU接受过中短期课程培训以建立可持续研究的工作人员 容量。到项目结束时，AKU的教职员工将能够进行高质量的HPV研究，发表在 国际公认的期刊，举办培训下一代HPV科学家的课程，以及 独立获得校外补助金，以支持他们的工作。

ABSTRACT Human papillomavirus (HPV) is the most common sexually transmitted infection in the world with 85% of infections occurring in low and lower middle income countries (LMIC). Nearly all cervical cancer is due to persistent HPV infection with 87% of all cervical cancer deaths occurring in LMIC. Detecting, preventing, and treating HPV infection is thus a major health priority for the country and the region. Aga Khan University East Africa (AKU) is a premier medical and nursing academic institution uniquely situated to address global infectious diseases and HPV. It is a growing university with campuses in Kenya, Uganda, and Tanzania, and it has initiated the first clinical infectious diseases (ID) fellowship for medical doctors in East Africa. However, in order to achieve its goal to become a top research institution, AKU needs further research capacity building and support to train a critical mass of health researchers at AKU with in-depth scientific expertise. The objectives of this proposal are to: 1) increase research into the prevention, detection, and treatment of HPV infection and its impact on cancer; 2) strengthen the capacity of AKU to conduct research in infectious diseases; and 3) expand knowledge and skills in clinical research across AKU campuses in East Africa. The proposed research training program will be led by Drs. Marleen Temmerman and Michael Chung who will be Multiple Program Directors. Together, they will partner AKU with the University of Washington (UW) and its extensive history of successfully implementing research training programs in Kenya. The UW has trained hundreds of Kenyans in health research for over 30 years. UW is also home to a world-renowned HPV Research Group led by faculty experts from the UW and the Fred Hutchinson Cancer Research Center. Drs. Temmerman and Chung will establish a joint research training program for Kenyans with three tracks of varying duration. The long-term track will allow AKU ID fellows to earn a UW Master’s in Public Health (MPH) degree by taking classes in Seattle and conducting fieldwork in Kenya; the medium-term track will invite AKU medical and nursing faculty researchers for 3 months of classes at UW followed by a mentored project in Kenya; and the short-term track will give an opportunity for AKU faculty, staff, and students throughout East Africa to learn grant and manuscript writing and leadership skills through in-person workshops in Nairobi, Kenya and online courses from the UW. A total of 3 AKU ID fellows will earn MPH degrees at the UW, 10 AKU faculty members will undergo non-degree coursework at the UW, and hundreds of trainees will take the workshops and online courses. After graduating, the ID fellows will be offered academic medical positions at AKU and join faculty and staff who have been trained in the medium- and short-term courses at AKU to build sustainable research capacity. By the end of the program, AKU faculty will be able to conduct quality HPV research, publish in internationally-recognized journals, conduct courses to train the next generation of HPV scientists, and independently obtain extramural grants to support their work.