COMPARISON SOFTWARE TO ASSESS NGS ACCURACY & BOOST TRANSLATIONAL RESEARCH

项目摘要 SolveBio是一个基于云的数据平台，用于生物制药、临床和转化研究。这个 本项目的目标是实现一个基于图形用户界面的比较软件套件 为了跨重复灵活地比较患者的下一代测序(NGS)结果， 分析、商业供应商、生物制品和时间点，初步应用于 评估液体活检的准确性。液体活检是一种新兴的非侵入性检查方法 筛选和监测可采取行动的突变，但技术和生物障碍依然存在。 比较和评估由不同分析方法产生的NGS数据对于 大多数科学家个人。解决这一挑战有可能在以下方面促进进展 采用精密肿瘤学，促进下一代更广泛的应用 测序技术，为患者提供更高效的临床护理。

Project Summary SolveBio is a cloud-based data platform for biopharma clinical and translational research. The goal of this project is to implement a graphical user interface-based comparison software suite to flexibly compare next generation sequencing (NGS) results for patients across replicates, assays, commercial vendors, biospecimens, and timepoints, with an initial application in assessing liquid biopsy accuracy. Liquid biopsy is an emerging non-invasive method for screening and monitoring actionable mutations but technological and biological hurdles remain. Comparing and evaluating NGS data generated by different assays is difficult to impossible for most individual scientists. Solving this challenge has the potential to catalyze progress in the adoption of precision oncology and facilitate the broader application of next-generation sequencing technologies to provide more efficient clinical care to patients.