Elucidating the Necessary Components and Mechanisms of Cognitive Training

项目名称：阐明认知训练的必要组成部分和机制 项目日期：2020年6月1日-2021年3月31日 项目编号：U01AG062370 这一项目的持续目标(赠款标题：阐明必要的组成部分和机制 认知训练，U01AG062370)和相关补充是开发和评估协议以 研究老年人多项认知训练计划背后的行为和神经机制。Dr。 罗斯搬到克莱姆森大学，寻求批准将补助金转给克莱姆森分包合同 回到宾夕法尼亚州立大学、爱因斯坦大学和UAB大学，按原计划完成工作。总体目标和 该项目的目标是相同的，以下概述的变化主要是由于新冠肺炎。 因PI移至克莱姆森而发生的更改： 没有。罗斯博士获得了老龄化和认知领域的特聘主席职位。该职位包括无 两年的教学责任，这让她可以专注于研究。此外，罗斯博士将 在宾夕法尼亚州立大学保持教员附属职位，确保保持对宾夕法尼亚州立大学系统的访问。罗斯医生 通过ZOOM与研究人员和合作调查人员举行几次常设会议，以确保清晰的沟通。 这些措施包括每周一次的实验室会议以审查研究进展，以及每周一次的联合工作人员会议 关于任何项目困难的调查人员和工作人员。此外，所有工作人员都会单独与罗斯博士会面 每隔一周和每月与健康老龄化中心的行政领导一起发表研究或 人事问题。Sliwinski博士(MPI)将继续以Site PI的身份监督宾夕法尼亚州立大学的分包合同。vt.给出 这些已经在实施的多条沟通渠道，罗斯博士将能够监督 克莱姆森大学的这项研究。 新冠肺炎带来的变化： 最初的项目包括四次面对面的数据收集访问和两次额外的核磁共振面对面访问 二次抽样。由于新冠肺炎的缘故，我们重新设计了所有研究材料，并重新预算了增加设备的预算，以 允许我们远程收集所有数据。为了促进项目向前推进，特别是考虑到人们的关切 关于2020-2021年冬季可能出现的新一波COVID疫情，我们正在转向远程数据采集。 这一决定是NIA在协商并获得批准后作出的。这些变化将使我们能够收集 使用研究提供的认知、心理社会、日常功能和自我报告的感觉功能 笔记本电脑在基线、后测试和随访时。智能手机的数据收集过程没有改变，而且仍然 包括在整个研究期间每天实施的认知和心理社会措施。我们正在使用 NIA资助的M2C2移动电话日常评估平台(移动测量方法 认知变化；U2C AG060408)，在过去的八个月里使用了多部手机进行了试点。 我们还与成熟的在线评估和培训公司(Posit Science， TestMyBrain和iFunction)包括已建立的远程数据收集评估以及较新的评估 为本研究目的而开发或改编的(DECA，ANT)。这在新的 以及在较新的远程数据收集出现技术困难的情况下进行既定的评估。 其他变化： 鉴于远程数据收集的复杂性，我们已邀请Christine Phillips博士作为 这个项目。菲利普斯博士是克莱姆森大学的研究助理教授，与罗斯博士合作超过6年 好几年了。她将协助罗斯博士监督这项研究的所有方面。

Project Title: Elucidating the Necessary Components and Mechanisms of Cognitive Training Project Dates: June 1, 2020-Mary 31, 2021 Project Number: U01AG062370 The continued goal of this project (grant title: Elucidating the Necessary Components and Mechanisms of Cognitive Training, U01AG062370) and associated supplement is to develop and evaluate the protocol to examine behavioral and neural mechanisms underlying multiple cognitive training programs in older adults. Dr. Ross relocated to Clemson University and seeks approval to move the grant to Clemson with subcontracts returned to Penn State, Einstein, and UAB to complete the work as originally planned. The overall goal and aims of the project are the same with changes outlined below primarily due to COVID-19. Changes due to PI move to Clemson: None. Dr. Ross has attained an Endowed Chair position in Aging and Cognition. This position includes no teaching responsibilities for two years which allows her to focus on research. Additionally, the Dr. Ross will maintain a faculty affiliate position at Penn State ensuring maintained access to Penn State systems. Dr. Ross holds several standing meetings with study staff and coinvestigators via zoom to ensure clear communication. These included weekly lab meetings to review study progress and weekly joint staff meetings with co- investigators and staff regarding any project difficulties. Additionally, all staff meet individually with Dr. Ross every other week and with the Center for Healthy Aging’s administrative leader monthly to address study or personnel issues. Dr. Sliwinski (mPI) will continue to oversee the Penn State subcontract as site PI. Given these multiple lines of communication which are already being implemented, Dr. Ross will be able to oversee the study from Clemson University. Changes due to COVID-19: The original project involved four in-person data collection visits and two additional in-person visits for the MRI subsample. Due to COVID-19, we redesigned all study materials and re-budgeted for additional equipment to allow us to collect all data remotely. In order facilitate the project moving forward, especially given concerns about possible additional waves of COVID in the winter of 2020-2021, we are moving to remote data collection. This decision was reached in consultation, and with approval, by NIA. The changes will allow us to collect cognitive, psychosocial, everyday functioning and self-reported sensory functioning using study-provided laptops at baseline, posttest, and follow-up. The smartphone data collection process has not changed and still includes cognitive and psychosocial measures administered daily throughout the study period. We are using the NIA-funded M2C2 mobile phone platform for daily assessments (Ambulatory Methods for Measuring Cognitive Change; U2C AG060408) which has been piloted using multiple phones over the last eight months. We have also partnered with established online assessment and training companies (Posit Science, TestMyBrain, and iFunction) to include established remote data collection assessments as well as newer ones developed or adapted for the purpose of this study (DECA, ANT). This provides significant overlap across new and established assessments in case there are technical difficulties with the newer remote data collection. Other changes: Given the complexity of remote data collection, we have included Dr. Christine Phillips as a Co-Investigator on the project. Dr. Phillips is a research assistant professor at Clemson and has worked with Dr. Ross for over 6 years. She will assist Dr. Ross with overseeing all aspects of the study.