New treatments for Huntington’s disease

亨廷顿氏病（HD）是一种破坏性的神经退行性疾病，其与阿尔茨海默氏病和帕金森氏病（即痴呆样认知缺陷）具有若干特征。目前还没有治愈HD的方法。使用HD的小鼠模型和针对导致HD的事件级联的两个不同水平的相关药物（即N-乙酰半胱氨酸和去铁酮）的组合，我们将减缓疾病的进展并纠正大脑内的功能障碍。

Huntington’s disease (HD) is a devastating neurodegenerative disorder which shares several features with Alzheimer’s and Parkinson’s disease (i.e. dementia-like cognitive deficits). There is currently no cure for HD. Using a mouse model of HD and a combination of relevant drugs (i.e. N-Acetylcysteine and deferiprone) targeting two distinct levels of the cascade of events leading to HD, we will slow down the progression of the disease and correct dysfunctions within the brain.