Mechanisms of Trauma-Induced Coagulopathy

计划摘要/摘要 我们创伤研究中心培训计划的基本目标是激励下一个 一代外科实习生追求包括基础科学和翻译在内的职业生涯 调查。在外科科学家越来越少的时候，这笔培训拨款对于维持 临床上活跃的外科医生参与基础研究。虽然我们中心的主要关注点是创伤诱导 凝血障碍和炎症，我们相信我们计划内机会的多样性，以及一般 凝血/炎症过程适用于其他学科，确保与任何外科手术相关 实习生。我们的次要目标是在学术创伤外科领域招募有能力的外科医生 缺乏研究已经成为一场全国性的危机。创伤仍然是美国人死亡的主要原因 46岁以下的人出血是这些可预防的死亡的主要原因。 因此，在这一领域进行基础和转化性调查的必要性是至关重要的，也是我们的灵感所在。 我们计划的设计是为期两年的全日制基础调查 主要在科罗拉多大学安舒茨医学院内成熟的外科研究实验室 园区，辅以从我们地区I级Ernest的前瞻性临床研究中生成的患者数据 丹佛健康中心的E-Moore休克创伤中心。实验工作将集中在破坏机制上 凝血-炎症动态平衡，包括蛋白质组学、代谢组学和 基因组学。 这项基础研究的主要资金将是1RM1GM13968 NIGMS资助的《实现血栓炎症平衡》，NHLBI资助的UM1HL120877策略， 以及国防部资助的DOD-W81XWH-12-2-0028“创伤急性凝固症”。 临床研究将主要由国防部W81XWH-12-2-0028 W81XWH-16-D-0024“链接 在创伤和急救服务临床研究网络(LITES)的调查以及一些 机构和行业支持试验。外科研究员将开始参与 在连续两年的普外科住院医师第二年或第三年(PGY 2或3)后参加该计划。 我们鼓励在研究生院接受培训，攻读硕士、公共卫生硕士和博士等高级学位 医学教育。 与过去一样，我们每年为四个职位申请资金，按顺序排列，以便第一和第二个职位 年度研究员被分配到我们的核心实验室。

Program Summary/Abstract The fundamental objective of our Trauma Research Center Training Program is to inspire the next generation of surgical trainees to pursue a career that includes basic science and translational investigation. At a time when surgical scientists are becoming rare, this training grant is critical to maintain the participation of clinically active surgeons in basic research. While our Center’s primary focus is Trauma-Induced Coagulopathy and Inflammation, we believe the diversity of opportunities within our Program, and general applicability of the coagulation/inflammation process to other disciplines, ensures relevance to any surgical trainee. Our secondary objective is to recruit capable surgeons to the field of academic trauma surgery in which lack of research has become a national crisis. Trauma remains the leading cause of death in the US for individuals younger than 46 years of age with bleeding the primary cause of these preventable deaths. Hence the need for basic and translational investigation in this area is essential and remains our inspiration. The design of our Program is a two-year full-time commitment to basic investigation conducted primarily in well-established surgical research laboratories within the University of Colorado Anschutz Medical Campus, supplemented by patient data generated from prospective clinical studies at our regional Level I Ernest E Moore Shock Trauma Center at Denver Health. Experimental work will focus on the mechanisms disrupting coagulation-inflammatory homeostasis, and includes investigation with proteomics, metabolomics, and genomics. The major funding for this basic research will be the 1RM1GM13968 “Resuscitation Strategies for Achieving Thrombo-inflammation Homeostasis” funded by NIGMS, UM1HL120877 TACTIC funded by NHLBI, and DOD-W81XWH – 12-2-0028 “Acute Coagulopathy of Trauma” funded by the Department of Defense. Clinical studies will be funded dominantly by the DOD W81XWH–12-2-0028 W81XWH-16-D-0024 “Linking Investigation in Trauma and Emergency Service Clinical Research Network” (LITES) as well as a number of institution and industry supported trials. The surgical research fellows will commence participation in the Program after the second or third year of general surgery residency (PGY 2 or 3) for two consecutive years. We encourage pursuit of advanced degrees, e.g. MS, MPH, and PhD, with training in the School of Graduate Medical Education. As in the past, we are requesting funding for four positions annually, sequenced so that first and second year fellows are assigned to our core laboratories.