UCSF Comprehensive Lab Animal Monitoring System

描述（由申请人提供）：该共享设备补助金用于12室综合实验室动物监测系统（CLAMS），该系统能够有效和精确地测量小鼠的摄食，基础代谢，运动活动和体温调节。这些参数的准确测量对于阐明肥胖和代谢性疾病的机制至关重要。目前，没有类似的设备是访问越来越多的UCSF研究人员谁是肥胖和代谢综合征的研究。无法通过常规方法测量研究动物的关键代谢参数阻碍了该领域的研究进展。在本申请中，一组UCSF研究人员描述了他们的NIH支持的研究项目，这些项目将从CLAMS系统的收购中受益匪浅。CLAMS系统，如果资助，将被整合到UCSF代谢核心，这将是管理和维护由指定人员在UCSF糖尿病中心。已制定详细的管理计划，以确保仪器的成本效益运作。随着肥胖症、2型糖尿病和代谢性疾病的流行率不断上升，拟议仪器的安装将大大提高现有研究工作的能力，并将吸引更多的研究人员研究肥胖症和代谢性疾病。

DESCRIPTION (provided by applicant): This shared equipment grant is for a 12-chamber Comprehensive Lab Animal Monitoring System (CLAMS) that enables efficient and precise measurements of feeding, basal metabolism, motor activities, and thermoregulation in mice. The accurate measurements of these parameters are essential for elucidating the mechanisms underlying obesity and metabolic diseases. Currently, no comparable equipment is accessible to an increasing number of UCSF investigators who are conducting research on obesity and metabolic syndromes. The inability to measure key metabolic parameters in research animals by conventional methods has impeded research progress in this field. In this application, a group of UCSF investigators have described their NIH-supported research projects that would significantly benefit from the acquisition of a CLAMS system. The CLAMS system, if funded, will be integrated into the UCSF Metabolic Core, which will be managed and maintained by designated personnel at the UCSF Diabetes Center. Detailed management plan has been formulated to ensure cost-effective operation of the instrument. With prevalence of obesity, type 2 diabetes and metabolic diseases on the rise, the installation of the proposed instrument would dramatically increase the capacity of existing research efforts, and will attract an even larger number of investigators to study obesity and metabolic disorders.