Multiwavelength diode laser system for PDT

描述(由申请人提供)：我们是一个由10名多学科调查人员组成的小组，代表加州大学欧文分校的6个系，拥有11项联邦资助的研究补助金，受此仪器申请的影响。我们正在为多波长光动力疗法(PDT)连续波光源寻求资金，该光源将安装在贝克曼激光研究所久负盛名的NIH-NCRR生物医学技术资源中心(P41-RR01192，激光微束和医学计划，LAMMP)内并得到支持。LAMP设施致力于定义和理解与使用光作为诊断和治疗工具有关的广泛问题。BLI自上世纪80年代初以来一直致力于发展、推进和翻译PDT科学，S中心在技术开发方面具有非常雄厚的基础。我们迫切需要一种商用的、用户友好的多波长PDT光源，并在我们的NIH资源中进行容纳和管理。在美国，有能力执行该提案中所述项目的中心很少。光动力疗法的科学在欧洲和亚洲要先进得多。拟议的项目是作为试点/可行性研究启动的，使用的是过时的光源，限制了PDT科学向临床应用的转化。我们中心迫切需要升级和利用商业上可用的技术来支持这项研究，并将我们的技术转化为患者使用。如果不能获得这样的工具，这些由美国国立卫生研究院资助的调查人员的持续进展就会受到阻碍。预计所要求的仪器将对加州大学欧文分校的研究界和其他方面产生重大的整体好处，这是基于LAMP现有的强大影响及其向同事和合作者传播新发现的基础上的。

DESCRIPTION (provided by applicant): We are a group of 10 multi-disciplinary investigators representing 6 departments at the University of California, Irvine with 11 federally funded research grants impacted by this request for instrumentation. We are seeking funds for a multi-wavelength photodynamic therapy (PDT) continuous wave light source to be housed and supported within the well-established NIH-NCRR Biomedical Technology Resource Center (P41-RR01192, Laser Microbeam and Medical Program, LAMMP) at the Beckman Laser Institute. The LAMMP facility is dedicated to defining and understanding broad issues related to the use of light as a diagnostic and therapeutic tool. BLI has been involved in developing, advancing and translating PDT science since the early 1980's and our center has a very strong foundation in technology development. There is an urgent need for a commercial, user-friendly multi-wavelength PDT light source to be housed and managed within our NIH resource. There are very few centers in the United States capable of performing the projects described in this proposal. PDT science is much more advanced in Europe and Asia. The proposed projects were initiated as pilot/feasibility studies using obsolete light sources limiting translation of the PDT science to clinical application. There is a critical need at our center to upgrade and utilize commercially available technology to support this research and to translate our technologies for patient use. Continued progress for these NIH-funded investigators is hampered without access to such an instrument. It is expected that the requested instrumentation will have a significant overall benefit to the UC Irvine research community and beyond, based on the existing strong impact of the LAMMP and its dissemination of new discoveries to colleagues and collaborators.