Purchase of a CD Spectropolarimeter

描述(申请人提供)：科罗拉多大学博尔德分校的一组研究人员正在申请一台最先进的圆二色光谱偏振仪(CD)，用于生物分子研究。CD是表征生物分子二级和三级结构的关键生物物理工具，可以提供对结构以及折叠和结合热力学的见解。目前，博尔德园区没有能够正常工作的CD仪器，这种资源的缺乏阻碍了NIH资助的几个研究项目的进展。这些项目涵盖广泛的生物分子科学，包括治疗性蛋白质及其聚集特性的研究(Carpenter，Randolph)、针对神经元的膜蛋白质和肽疗法(Falke，Yen)、细菌发病机制(SOUSA)、端粒生物学(Wuttke)、活体成像金属传感器的设计(Palmer)和RNA生物科学(Batey和Pardi)。此外，科罗拉多大学博尔德分校在分子生物物理学和药物生物技术方面拥有成熟的课程，我们预计一旦仪器设备建立起来，用户基础将会扩大。科罗拉多大学博尔德分校迫切需要一台现代化的CD仪器，这一设备的收购将对广泛的生物医学研究项目产生广泛的影响。

DESCRIPTION (provided by applicant): A group of researchers at the University of Colorado, Boulder, are requesting a state-of-the-art circular dichroism spectropolarimeter (CD) for biomolecular studies. CD is a key biophysical tool for the characterization of secondary and tertiary structure of biomolecules, and can provide insights into structure, as well as folding and binding thermodynamics. There is currently no functioning CD instrumentation on the Boulder campus, and this lack of resources has impeded progress in several NIH-funded research programs. These programs span a wide range of biomolecular science, including the study of therapeutic proteins and their aggregation properties (Carpenter, Randolph), membrane proteins and peptide therapeutics targeting neurons (Falke, Yin), bacterial pathogenesis (Sousa), telomere biology (Wuttke), the design of metal sensors for in vivo imaging (Palmer) and RNA bioscience (Batey and Pardi). Furthermore, the University of Colorado at Boulder has well-established programs in Molecular Biophysics and Pharmaceutical Biotechnology, and we anticipate the user base will grow once the instrumentation is established. A modern CD instrument is urgently needed at CU-Boulder, and acquisition of this equipment will have a broad impact across a wide range of biomedical research programs.