Purchase of a Typhoon Phosphorimager-Fluoroimager for the Keck Biophysics Facilit

描述（由申请人提供）：这是一份购买最先进的台风荧光成像仪/磷光成像仪作为西北大学研究界共享仪器的提案。该仪器为荧光和化学荧光凝胶和印迹的表征提供了多功能的成像能力和卓越的灵敏度。这些能力是目前在西北大学正在进行的许多美国国立卫生研究院资助的项目所需要的（包括但不限于本申请中详细描述的15个项目），而西北大学或附近的其他学术机构则不具备这些能力。该仪器将被整合到凯克生物物理设施中，凯克生物物理设施是一个众所周知的共享设备和技术专长资源，每周7天，每天24小时为北大的研究人员提供服务。台风成像仪为NU生命科学研究界提供的能力的必要性不容忽视：每天约有40个研究小组将受益于这种能力；研究项目包括那些寻求了解基因组结构和功能的基本方面，真核细胞分裂和分化的核心信号通路，或各种人类疾病的分子起源（例如，亨廷顿氏病，帕金森病，阿尔茨海默病，多囊肾病，慢性阻塞性肺病）的研究项目，以及那些旨在开发革命性药物和创新治疗策略的研究项目。以及脑部和骨骼疾病。

DESCRIPTION (provided by applicant): This is a proposal to acquire a state of the art Typhoon Fluoroimager/Phosphoimager as a shared instrument for the Northwestern University research community. This instrument provides versatile imaging capabilities and exceptional sensitivity for characterization of fluorescent and chemifluorescent gels and blots. Such capabilities are required by many NIH-funded projects currently underway at NU (including, but not limited to, the 15 projects described in detail in this application) and are not available at Northwestern or at other nearby academic institutions. The instrument will be integrated in the Keck Biophysics Facility - a well known resource of shared equipment and technical expertise available to NU researchers on a 24 hours a day, 7 days a week basis. The need for the capabilities provided by the Typhoon imager for the NU Life Sciences research community cannot be underscored: about 40 research groups would benefit from such capabilities on a daily basis; research projects include those seeking to understand basic aspects of genomic structure and function, signaling pathways central to eukaryotic cell division and differentiation, or molecular origins of various human diseases (e.g., Huntington's disease, Parkinson's disease, Alzheimer's disease, polycystic kidney disease, chronic obstructive pulmonary disease), as well as those aiming to develop revolutionary drugs and innovative therapeutic strategies for cancer, infertility, and brain and bone disorders.