IMAGING, METHODOLOGY AND STATISTICS CORE

成像、方法学和统计学（IMS）核心将通过提供标准方法和工作人员支持，整合和协调3个项目中神经成像和统计学资源的有效和一致利用，这些方法和支持将随时为研究者所用。国际监测系统核心将作为数据采集、处理和评价以及开发新的分析和软件的技术核心。通过这种方式，IMS核心将成为每个项目的一个组成部分，并支持开始解决PIB在对照组和轻度认知障碍和阿尔茨海默病（AD）患者以及帕金森病痴呆（PDD）和路易体痴呆（DLB）患者大脑中纤维状淀粉样蛋白PET成像检测中的一般效用，灵敏度和特异性问题的研究。 IMS核心的主要目的是：1）应用定量神经成像方法测量AD疾病谱中的淀粉样蛋白结合、脑代谢率和海马/脑形态学; 2）比较AD疾病谱中以及PDD和DLB中的淀粉样蛋白结合、代谢率和脑结构横截面; 3）确定神经成像测量在同一受试者组中跨时间和相对于认知表现的时间和空间特征。本申请中描述的项目研究代表了对任何淀粉样蛋白成像示踪剂进行的第一次完全定量的临床评价。核心将通过进行检查组识别的分析（例如，统计分类），通过应用统计建模来探索神经成像测量和疾病严重性测量之间的关系（例如，MMSE）和涉及“痴呆转换”的问题。IMS核心活动将在横截面和纵向基础上进一步确认PIB PET成像的临床应用。

The Imaging, Methodology and Statistics (IMS) core will integrate and coordinate efficient and consistent utilization of neuroimaging and statistics resources across the 3 program projects by providing standard methods and staff support that will be readily accessible to investigators. The IMS core will serve as a technical core for data acquisition, processing, and evaluation and for the development of novel analyses and software. In this manner, the IMS core will be an integral component of each project and support research that begins to address issues of the general utility, sensitivity, and specificity of PIB in the PET imaging detection of fibrillar amyloid in the brain of controls and in patients with mild cognitive impairment and Alzheimer's disease (AD) and also in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). The central aims of the IMS cores are to: 1) apply quantitative neuroimaging methods to measure amyloid binding, cerebral metabolic rate, and hippocampal/brain morphometry across the AD disease spectrum; 2) compare amyloid binding, metabolic rate, and brain structure cross-sectionally across the AD disease spectrum and in PDD and DLB; 3) determine temporal and spatial characteristics of the neuroimaging measures across time and relative to cognitive performance in the same subject groups. The program project research described in this application represents the first fully quantitative clinical evaluation of this kind performed on any amyloid imaging tracer. The core will perform a careful evaluation of the utility of PIB PET across the AD disease spectrum and in PDD and DLB by performing analyses that examine group identification (e.g., statistical classification), by applying statistical modeling to explore relationships among neuroimaging measures and measures of disease severity (e.g., MMSE) and questions involving "dementia conversion". The IMS core activities will further validate PIB PET imaging for clinical application on a cross-sectional and longitudinal basis.