M-CPP PET SCANNING IN ALCOHOLISM: EFFECTS OF SERTRALINE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 临床前和临床工作的一个重要机构证明了5-羟色胺系统参与酒精中毒。 最近发表的两项成功的5-羟色胺再摄取抑制剂（如舍曲林或左洛复）的临床试验为该领域带来了重大的希望。 这两项研究都依赖于将酒精中毒患者分成亚组来揭示药物的疗效。 本研究的目的有两个方面。 首先，确定一种名为血清素的化学物质在有酒精滥用问题的人大脑中的作用，并观察血清素功能的测量是否有助于预测谁会对治疗产生成功的反应。 第二，研究药物舍曲林，它与大脑的血清素系统，是有效的治疗酗酒问题的人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A significant body of preclinial and clinical work demonstrates the involvement of the serotonin system in alcoholism. Recent publication of two successful clinical trials of serotonin reuptake inhibitors (e.g. sertraline or Zoloft) holds signicicant promise for the field. Both of these studies depended upon the division of their alcoholic patients into subgroups to reveal the medications' efficacy. The purpose of this study is two-fold. First, to determine the effect of a chemical called serotonin in the brains of people with alcohol abuse problems and to see if measurements of serotonin functioning can help predict who will respond successfully to treatment. Second, to study whether the medication Sertraline, which works with the brain's serotonin system, is effective in the treatment of people with alcohol abuse problems.