NEW DIRECTIONS IN THE GENETICS OF IMPULSIVITY AND AGGRESSION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是利用已知的降钙素相关基因多态性，调查人格障碍患者冲动性攻击行为的遗传贡献。 冲动性攻击行为在人格障碍患者中普遍存在，并占与这些障碍相关的发病率的很大一部分。 在人格障碍患者中，研究降钙素相关基因的基因型与冲动性攻击行为之间的关系是合乎逻辑的，因为：（1）在具有冲动性攻击行为的人格障碍患者中，中枢神经系统的降钙素能活性降低;（2）冲动性攻击行为至少部分可遗传; 3）已经描述了与马诺宁相关的多态性（基因型的变异性），允许表征个体受试者中的基因型。 此外，我们建议利用催乳素对芬氟拉明的反应来测量中枢5-羟色胺功能，以便与基因型和临床现象进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the proposed study is to investigate the genetic contribution to impulsive aggressive behavior in patients with personality disorders, utilizing known polymorphisms in serotonin-related genes. Impulsive aggressive behavior is prevalent in patients with personality disorders and accounts for a substantial portion of the morbidity associated with these disorders. It is logical to investigate the association between genotype in serotonin-related genes and impulsive aggression in patients with personality disorders, in light of the observations that: 1) decreased serotongergic activity in the central nervous systgem has been demonstrated in personality disordered patients with impulsive aggressive behavior; 2) impulsive aggression has been shown to be at least partially heritable; 3) serotonin-related polymorphisms (variability in genotype) have been described, allowing for the characterization of genotype in individual subjects. In addition, we propose to measure central serotonin function utilizing the prolactin response to fenfluramine to allow for comparisons with both genotype and clinical phenomena.