PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY

精神分裂型人格的认知药理学

• 批准号: 7953656
• 负责人: Larry J Siever
• 金额: $ 0.15万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953656
• 关键词: Accounting; Activities of Daily Living; Clinical; Clinical Research; Cognition; Computer Retrieval of Information on Scientific Projects Database; Episodic memory; Funding; Grant; Guanfacine; Impairment; Institution; Maintenance; Measures; Memory; Patients; Performance; Personality; Pharmacology; Process; Research; Research Personnel; Resources; Schizophrenia; Schizotypal Personality Disorder; Short-Term Memory; Source; Stimulus; Symptoms; Testing; Time; United States National Institutes of Health; Visual attention; Visuospatial; base; executive function; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: 1) SPD patients will demonstrate impairment across verbal and visuospatial stimuli in several different tests sensitive to central executive functions (i.e., maintenance plus manipulation, dual-task processing: time sharing, and context processing) that is disproportionate to their maintenance-only performance, similar to previous results in schizophrenia. 2) These deficits will not be accounted for by visual attention/perceptual integration deficits or clinical symptoms. 3) Performance-based measures of functional capacity will be impaired in SPD and performance on these tasks will be related to central executive functioning, including context processing, dual-task time sharing, and maintenance and manipulation working memory. 4) Guanfacine will improve performance in SPD patients only on the maintenance plus manipulation task, context processing, dual-task time sharing, as well as on the functional capacity measures. 5) No significant improvement with guanfacine will be seen on maintenance only working memory, simple memory span, and measures of episodic memory.

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