SLEEP DEPRIVATION AND FMRI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究采用了最先进的功能性磁共振成像（fMRI）方法来绘制和量化睡眠剥夺后执行功能和警惕任务受损的神经相关性。 具体目标1：采用功能性磁共振成像（fMRI）技术，研究24小时睡眠剥夺对正常人执行功能（Stroop）和警觉（听觉odd-ball）任务时神经网络的影响。 具体目标二：测量阻塞性睡眠呼吸暂停（OSA）患者睡眠剥夺前后fMRI激活模式的变化，如具体目标1所述。 我们将这些结果与正常对照组的结果进行比较。 假设2：睡眠剥夺的OSA患者执行功能和警觉性测试的激活模式将超过基线。 然而，我们预测激活的增加将小于正常对照组，反映了代偿储备的减少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study applies state-of-the-art advanced functional magnetic resonance imaging (fMRI) methods to map and quantify the neural correlates of impaired performance on executive function and vigilance tasks after sleep deprivation. Specific Aim 1: To use functional magnetic resonance imaging (fMRI) to examine the effects of 24 hours of sleep deprivation on neural networks during executive function (Stroop) and vigilance (auditory odd-ball) tasks in normal controls. Specific Aim 2: To measure changes in fMRI activation patterns before and after sleep deprivation in patients with obstructive sleep apnea (OSA) as outlined in Specific Aim 1. We will compare these results to those obtained in normal controls. Hypothesis 2: Activation patterns on tests of executive function and vigilance in sleep-deprived OSA patients will increase over baseline. We predict, however, that the increase in activation will be smaller than in normal controls reflecting a reduced compensatory reserve.