Long Term efficacy of rTMS in Managing MTBI-related Headache

摘要 持续性头痛是军事人员最常见的衰弱症状之一。 患有轻度脑外伤(MTBI)。除了头痛，这些患者还遭受着 从相关的情绪和注意力缺陷。传统的止痛药还没有被证明是 有效地管理这些衰弱的症状，包括不良副作用和虐待 很复杂。我们的初步研究表明，一周的非侵入性中枢 左侧运动重复经颅磁刺激的神经调节方法 皮质(LMC)可显著缓解MTB相关头痛症状，最长可达一个月。 与假对照相比，有显著的副作用。正在进行的患者前瞻性临床调查 接受治疗也表明rTMS提供了一种可行的非侵入性长期治疗方案。 用于MTBI相关头痛(MTBI-HA)管理。这项建议旨在进一步验证长期- RTMS治疗MTBI-HA 2~3个月的远期疗效比较 在LMC，主动rTMS(A组)到假rTMS(B组)：1)降低强度、频率和 MTBI-HA的持续时间和止痛药的总体使用情况；2)改善生活质量、情绪和 MTBI患者的功能。

Abstract Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI). Along with headaches, these patients also suffer from associated mood and attentional deficit. Conventional analgesics have not been shown to be effective in managing these debilitating symptoms and consist of untoward side effects and abusive complication. Our preliminary study indicates a week long course of non-invasive central neuromodulation method called repetitive transcranial magnetic stimulation (rTMS) at the left motor cortex (LMC) can significantly alleviate MTB related headache symptoms up to one month without significant side effects in comparison to sham control. Ongoing prospective clinical survey in patients receiving treatments also suggests rTMS provides a feasible non-invasive long-term therapeutic option for MTBI related headache (MTBI-HA) management. This proposal aims to further validate the long- term effect of rTMS in managing MTBI-HA up to 2-3 months by comparing the treatment effect of active-rTMS (Group A) to sham-rTMS (Group B) at LMC in: 1) reducing the intensity, frequency and duration of MTBI-HA and the overall analgesic usage; and 2) improving quality of life, mood and functions in patients with MTBI.