To study the neuronal mechanism of acupunture analgesia

针刺镇痛的神经机制研究

• 批准号: 6794089
• 负责人: ALBERT Y. LEUNG
• 金额: $ 10.74万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794089
• 关键词: acupuncture /acupressure; alternative medicine; analgesia; behavior test; brain electrical activity; clinical research; functional magnetic resonance imaging; heat stimulus; human subject; neural information processing; pain; pain threshold; sensory mechanism

DESCRIPTION (provided by applicant): Acupuncture provides an alternative means of low cost and risk treatment option for pain. Despite the clinical efficacy of acupuncture suggested by a recent NIH consensus panel, the current principles, which govern the practice of acupuncture, are empirical. To facilitate the integration of acupuncture as a viable treatment modality for pain, a neuronal mechanism of acupuncture needs to be established. The long-term goal of the proposed study is to establish a new investigational approach that can correlate and establish the relationship between the analgesic mechanism of acupuncture and the corresponding dynamic brain activities. Based on the preliminary data that we have obtained in the past year, we propose to utilize the following for studying the neuronal mechanism of acupuncture analgesia in human volunteers: 1) a textbook acupuncture paradigm for treating acute pain, 2) a tonic acute thermal pain model, 3) a well established method of modality specific quantitative peripheral thermal neurosensory testing, and 4) functional Magnetic Resonance Imaging (fMRI) of the brain with a data-driven analysis model. This proposed study contains two phases with the following specific aims: 1) To quantitatively establish the effect of acupuncture on pain perception and thermal thresholds by using behavioral measurement and thermal neurosensory testing; 2) To establish the dynamic central nervous system response to the noxious thermal sensory stimulation with individually predetermined noxious thermal heat thresholds by using fMRI; 3) To establish the dynamic central nervous system response to acupuncture by using fMRI; 4) To assess the corresponding effect of acupuncture on peripheral acute thermal heat pain stimulation by using fMRI; 5) To assess the effect of variation in acupuncture needling on pain perception, peripheral thermal thresholds and correlated fMRI indices.

描述（由申请人提供）：针灸为疼痛提供了一种低成本和低风险的治疗选择。尽管最近NIH共识小组建议针灸的临床疗效，但目前指导针灸实践的原则是经验主义的。为了促进针灸作为一种可行的疼痛治疗方式的整合，需要建立针灸的神经机制。本研究的长期目标是建立一种新的研究方法，将针刺的镇痛机制与相应的动态脑活动联系起来。基于我们在过去一年中获得的初步数据，我们建议利用以下内容来研究人类志愿者针刺镇痛的神经机制：1）用于治疗急性疼痛的教科书针灸范例，2）强直性急性热疼痛模型，3）已建立的模态特异性定量外周热神经感觉测试方法，以及4）具有数据驱动分析模型的大脑的功能性磁共振成像（fMRI）。本研究分两个阶段进行，具体目的是：1）通过行为学测量和热神经感觉测试，定量研究针刺对痛觉和热阈值的影响; 2）通过功能磁共振成像，建立中枢神经系统对伤害性热感觉刺激的动态反应，并设定个体的伤害性热阈值; 3）利用fMRI建立针刺对中枢神经系统的动态反应; 4）利用fMRI评价针刺对外周急性热痛刺激的相应效应; 5）评价针刺手法的变化对痛觉、外周热阈值及相关fMRI指标的影响。