Core B - Statistical and Data Management

核心B：摘要 统计和数据管理核心(核心B)的总体目标是继续提供 支持总体计划项目赠款(PPG)的计算和分析资源 阐明轻度认知障碍(MCI)的分子神经生物学任务。更多 具体来说，核心B将协助研究设计、组织选择、数据管理、统计 分析，并解释结果，以确保每个PPG调查员的成功。具体来说， 该核心将提供数据管理，将现有的临床和神经病理数据联系起来 拉什阿尔茨海默病核心中心的拉什宗教秩序研究(RROS) (RADCC)，来自三个拟议计划项目拨款的细胞和分子研究结果 (Ppg)组件。为了实现这一点，核心B将：从 RROS临床和神经病理数据库；扩展、记录和维护 PPG数据库，并将RROS数据与PPG研究项目生成的数据合并 统计分析。此外，核心B将根据纳入/排除来确定符合条件的案例 PPG指定的标准，同时保持对临床和病理诊断的盲目性。 最后，为研究设计提供统计支持，准备跨项目的所有分析数据集， 根据需要进行统计分析，并确保解释和统计的准确性 结果的陈述。统计研究团队在以下方面经验丰富： 涉及人体组织样本的神经病理学研究。

Core B: Abstract The overall goal of the Statistics and Data Management Core (Core B) is to continue providing the computational and analytic resources to support the overall Program Project Grant (PPG) mission of elucidating the molecular neurobiology of mild cognitive impairment (MCI). More specifically, Core B will assist with study design, tissue selection, data management, statistical analysis, and results interpretation to ensure the success of each PPG investigator. Specifically, the core will provide data management linking existing clinical and neuropathological data from the Rush Religious Orders Study (RROS) housed in the Rush Alzheimer’s Disease Core Center (RADCC) with the cellular and molecular findings from the three proposed Program Project Grant (PPG) components. To accomplish this, Core B will: Extract and retrieve relevant data from the RROS clinical and neuropathological databases; expand, document, and maintain a PPG data library and merge RROS data with data generated by the PPG research projects for statistical analysis. In addition, Core B will identify eligible cases based upon inclusion/exclusion criteria specified by the PPG while maintaining blinding to clinical and pathological diagnoses. Finally, provide statistical support for study design, prepare all analytic data sets across projects, perform statistical analyses as needed, and assure statistical accuracy in interpretation and presentation of results. The statistical research team is experienced in the conduct of neuropathological studies involving human tissue samples.