University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)

项目总结：总体 这是一份修改后的申请，旨在建立爱荷华州大学的“鹰眼”智力与发展学院 残疾研究中心(HAWK-IDDRC)，我们的使命是提供一个全面的组织结构 将基础和临床研究整合到整个生命周期--从受孕到成年期--重点放在 智能发育障碍(IDDS)的预防、诊断、治疗和改善 对未得到充分服务的农村人口。HAWK-IDDRC包括四个组件：1)HAWK-IDDRC 研究项目将研究遗传和表观遗传/环境风险在幼儿中的相互作用 包括自闭症在内的发育障碍患者，并整合所有四个研究中心的服务；2)四个 研究核心将促进跨学科和转化性研究，包括：行政核心 (Ac)提供领导，确保具有成本效益和严谨的IDD研究，同时鼓舞人心 跨学科协作和创新；临床翻译核心(CTC)，将应用基础 通过简化患者招募和表型、生物库和 实施临床试验，以开发可用于整个生命周期的新疗法；a 发展基因组/表观遗传学核心(DGC)，它将使用RNA/外显子组/全基因组测序来 揭示内在遗传变异和外在(环境和经验)因素对 表观遗传调控及其与IDD的关联；以及神经回路和行为核心(NBC)， 它将评估动物和人类神经回路的发育和功能、电生理学和 行为；3)确保HAWK-IDDRC研究有效的传播和沟通计划 向科学界、教育工作者、政策制定者、政府官员和公众传达 参与和及时参与；4)教育计划，包括基础和临床科学家、实习生、 公众和受IDD影响的家庭，并将每月举办研讨会，指导年轻和有才华的人 调查人员专注于IDD研究，以及针对普通公众和IDD的教育计划 社区。鹰-IDDRC将整合和利用鹰眼现有的强大资源 州：1)全国知名的残疾人与发展中心；2)爱荷华州神经科学研究所； 3)爱荷华州大学残疾发展卓越中心(UCEDD)；4)爱荷华州领导层 神经发育障碍教育(LAND)计划。该中心将培育强大的现有 基础和临床科学家以及IDD社区及其家人之间的合作，以及 支持73个由联邦政府资助的项目(每年2800万美元)。爱荷华州稳定的、非暂时性的农村人口 和互联的远程医疗系统，独特地定位霍克-IDDRC调查人员进行纵向， 多代人的研究，爱荷华大学以此而闻名。通过提供基础设施来 HAWK-IDDRC将直接利用这些优秀的资源，成为IDD研究的主导力量。

PROJECT SUMMARY: OVERALL This is a revised application to establish the University of Iowa “Hawkeye” Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC), Our mission is to provide an organizational structure that fully integrates basic and clinical research across the lifespan—from conception to adulthood—that is focused on the prevention, diagnosis, treatment, and amelioration of intellectual developmental disabilities (IDDs), tailored to an underserved rural population. The Hawk-IDDRC includes four components: 1) the Hawk-IDDRC Research Project will examine the interaction of genetic and epigenetic/environmental risks in young children with developmental disabilities, including autism, and integrate services from all four research Cores; 2) Four Research Cores will facilitate interdisciplinary and translational research, including: an Administrative Core (AC) that provides leadership to ensure cost-effective and rigorous IDD research, while inspiring interdisciplinary collaboration and innovation; a Clinical Translational Core (CTC), which will apply basic science discoveries into clinical settings by streamlining patient recruitment and phenotyping, biobanking, and implementing clinical trials for the development of novel treatments that can be employed across the lifespan; a Developmental Genomic/Epigenetics Core (DGC), which will use RNA/exome/whole genome sequencing to uncover intrinsic genetic variation and the contributions of extrinsic (environmental and experiential) factors on epigenetic regulation, and the association of these with IDD; and a Neurocircuitry and Behavior Core (NBC), which will assess both animal and human neural circuit development and function, electrophysiology, and behavior; a 3) a Dissemination and Communication Plan that ensures Hawk-IDDRC research is effectively communicated to the scientific community, educators, policy makers, government officials, and the public, in an engaging and timely manner; and 4) an Educational Program, involving basic and clinical scientists, trainees, the public, and IDD-affected families, and will feature monthly seminars, mentoring of young and talented investigators focused on IDD research, and an educational program aimed at the lay public and IDD community. The Hawk-IDDRC will integrate and capitalize upon strong existing resources in the Hawkeye State: 1) the nationally renowned Center for Disabilities and Development; 2) the Iowa Neuroscience Institute; 3) Iowa’s University Center for Excellence in Developmental Disabilities (UCEDD), and 4) the Iowa Leadership Education in Neurodevelopmental Disabilities (LEND) program. The Center will foster strong existing collaborations between basic and clinical scientists, as well as the IDD community and their families, and support 73 federally funded projects ($28 million per year). The stable, non-transitory rural population in Iowa and an interconnected telehealth system uniquely position Hawk-IDDRC investigators to conduct longitudinal, multi-generational research, for which the University of Iowa is renowned. By providing the infrastructure to direct these outstanding resources, the Hawk-IDDRC will become a leading force in the study of IDD.