HIV and Aging SWG

项目总结/摘要 HIV和衰老SWG（SWG_1） 哈佛大学艾滋病研究中心（HU CFAR）的长期目标艾滋病毒与衰老 科学工作组（SWG）将与波士顿胡椒老年美国人独立组织合作 中心（又名波士顿胡椒中心），以1）建立和启用一个互动的，社区参与的网络， 加速发现人类免疫和身体功能下降的机制和生物标志物 艾滋病毒感染者老龄化（PLWH），2）建立资源基础设施，以支持与以下方面有关的跨学科建议： 艾滋病毒和老龄化，3）指导早期职业调查员（ECI）。这些目标将通过利用 独特的临床和基础资源和专业知识提供给胡CFAR和波士顿胡椒中心。 由于波士顿胡椒中心代表了一个研究人员联盟，该联盟专注于多个国家的老龄化问题。 机构，这个SWG将催化和使胡CFAR研究。 艾滋病毒和老龄化问题工作组响应艾滋病研究办公室的战略计划，该计划列出了“过早 老龄化和脆弱性”作为一个高度优先的研究，并确定为优先研究领域，由我们的社会 顾问委员。目标1将确定并吸引社区成员和研究人员参与研究 在艾滋病毒和老龄化的接口的利益，并召开活动，包括开幕研讨会和 联合赞助的（胡椒和CFAR）研讨会系列，以促进富有成效的互动，并将赞助一个 市政厅式的会议，以确定优先研究领域和艾滋病毒携带者之间的护理差距。目标2将建立一个 基础设施，以提供访问HU CFAR和胡椒中心的专业知识和资源， 合作研究。核心服务外展将包括身体功能评估（Pepper）和高级 实验室技术核心服务（CFAR）。Aim 3将与HU CFAR开发和 指导核心发展共同赞助的试点赠款，目标ECIs。RFA将强调使用核心 两个中心的服务，以及鼓励外展研究人员从两个中心和使用 教师实验室的资源。我们将建立一个内部赠款审查程序，以提供指导， 对ECI发起的提案的反馈。

PROJECT SUMMARY/ABSTRACT HIV and Aging SWG (SWG_1) The long-term objective of the Harvard University Center for AIDS Research (HU CFAR) HIV and Aging Scientific Working Group (SWG) is to collaborate with the Boston Pepper Older Americans Independence Center (a.k.a. Boston Pepper Center) to 1) build and enable an interactive, community-engaged network to accelerate discovery of mechanisms and biomarkers for decline in immune and physical function in people aging with HIV (PLWH), 2) create a resource infrastructure to support cross-disciplinary proposals related to HIV and aging, and 3) mentor Early Career Investigators (ECI). These goals will be achieved by leveraging unique clinical and basic resources and expertise available to the HU CFAR and the Boston Pepper Center. Since the Boston Pepper Center represents a consortium of investigators focused on aging across multiple institutions, this SWG will catalyze and enable HU CFAR research. The HIV and Aging SWG is responsive to the Office of AIDS Research strategic plan which lists, “Premature Aging and Frailty” as a high research priority and was identified as a priority research area by our community advisory members. Aim 1 will identify and engage community members and investigators with research interests at the interface of HIV and aging and convene activities that include an inaugural workshop and a jointly-sponsored (Pepper and CFAR) seminar series to facilitate productive interactions and will sponsor a town-hall style meeting to identify priority research areas and gaps in care among PLWH. Aim 2 will build an infrastructure to provide access to HU CFAR and Pepper Center expertise and resources to enable collaborative studies. Core service outreach will include physical function assessment (Pepper) and Advanced Lab Technologies Core services (CFAR). Aim 3 will collaborate with the HU CFAR Developmental and Mentoring Core to develop co-sponsored pilot grants that target ECIs. The RFA will emphasize use of core services from both centers, as well as encourage outreach to investigators from both centers and use of resources in faculty laboratories. We will create an internal grant review process to provide guidance and feedback on ECI-initiated proposals.