MBARARA UNIVERSITY RESEARCH ETHICS EDUCATION PROGRAM (MUREEP)

总结 在撒哈拉以南非洲的国际研究量正在增加，主要是因为非洲大陆的 疟疾、艾滋病毒和最近的非传染性疾病等疾病造成的独特的沉重负担。的 非洲大陆还面临着埃博拉和寨卡病毒等新出现的全球卫生挑战，所有这些都需要 测试新药、医疗器械或了解病理生理学。现在的许多研究包括 复杂的研究，如基因检测。国际研究的数量和复杂性的增长 对研究伦理委员会提出了挑战，因为他们中的大多数人没有充分准备审查 这些复杂的项目。资源有限的环境也呈现出独特的特点，如研究 主要是文盲的学习人口，可能破坏基本原则的父权社会 例如自主权和保密性。有必要对区域经济共同体和研究人员进行培训， 新的挑战，并制定如何应对这些挑战的方法。 为了满足这些需求，有必要在撒哈拉以南非洲建立研究伦理培训。我们提出 姆巴拉拉大学研究伦理教育计划（MUREEP），以建立多层次的研究伦理 乌干达的能力。姆巴拉拉科技大学（MUST）的独特定位， 实施必要的培训，以建立其研究人员，导师和REC的研究伦理能力， 以及其他地方机构。我们在凯斯西储大学（CWRU）的合作者， 哈佛大学、马凯雷雷大学和乌干达国家科学和技术理事会 将把他们在国际和本地研究道德方面的广泛专业知识带到团队中。我们建议：（1） 建立和实施一个可持续的硕士研究伦理学位，将毕业12名学生 在赠款期间。将公共卫生硕士学位与研究伦理相结合将导致公众 健康研究人员，在道德和谁将在就业市场上具有竞争力的广泛知识。2)提供一个 短期课程和能力建设活动，将在该区域培训至少525名参与者。 我们提出的短期课程计划将包括对遗传学研究和生物银行的道德规范的关注， 这是该地区和该地区的第一次。3)培养足够数量的教师和导师， 研究乌干达西南部的道德培训，并为教师提供培训和支持， 研究伦理学的教学/指导，以及4）加强在MUST和其他地方的REC的专业知识 机构职能体系

Summary The volume of international research in sub Saharan Africa is increasing largely because of the continent’s unique high burden of diseases such as malaria, HIV and more recently non-communicable diseases. The continent also faces emerging global health challenges such as Ebola and Zika virus all of which will require testing of new medicines, medical devices or understanding the pathophysiology. Many studies now include complex research such as genetic testing. The growth in volume and complexity of international research presents challenges to research ethics committees because most of them are inadequately prepared to review these complex projects. Resource limited settings also present unique features such as research among predominantly non-literate study populations, patriarchal society which may undermine fundamental principles such as autonomy and confidentiality. There is need to train RECs and researchers to become aware of these new challenges and devise ways of how to deal with them. To meet these needs, it is necessary to establish research ethics training in Sub Saharan Africa. We propose the Mbarara University Research Ethics Education Program (MUREEP) to build multi-level research ethics capacity in Uganda. Mbarara University of Science and Technology (MUST) is uniquely positioned, to implement the training needed to build the research ethics capacity of its investigators, mentors, and REC, as well as those of other local institutions. Our collaborators at Case Western Reserve University (CWRU), Harvard University, Makerere University and Uganda National Council of Science and Technology (UNCST) will bring their extensive expertise in international and local research ethics to the team. We propose to 1) establish and implement a sustainable MPH-Research Ethics degree at MUST that will graduate 12 students over the grant period. Combining a public health master’s degree with research ethics will result in a public health researcher with extensive knowledge in ethics and who will be competitive in the job market. 2) Offer a repertoire of short courses, and capacity building activities that will train at least 525 participants in the region. Our proposed program of short courses will include a focus on the ethics of genetics research and bio-banking, the first of its kind at MUST and in the region. 3) Create a critical mass of teachers and mentors for sustainable research ethics training in southwestern Uganda and provide training and support for faculty in teaching/mentoring in research ethics, and 4) Strengthen the expertise of REC at MUST and other local institutions.