Clinical Core

摘要 临床核心服务于南加州大学ADRC的主题、脑血管和代谢对认知的贡献 认知功能减退的血管和代谢危险因素；阿尔茨海默病的发病机制；以及预防 以及阿尔茨海默病相关疾病的治疗。核心的三个首要目标是：1)开发和 维持血管风险因素队列；2)促进本地、临床和转化性研究，包括早期阶段 临床试验；3)为国家协作提供血管疾病、生物标记物和成像方面的专业知识 首创精神。该核心解决了2011年国家阿尔茨海默病项目法案(NAPA)的许多重要目标： 转化工具、基础设施、试验设计和实施、新的药物靶点、关于照顾者支持的研究 招募和公民参与、生物标志物、健康差距、数据共享和使能技术。 Core登记并保留了主要的ADRC队列，即血管队列研究，脑研究 (尸检)研究，参与者共同参加附属研究。核心执行标准评估和 诊断、监督神经成像以及血液和脑脊液生物标记物的收集。对于这次更新，核心计划 增加血管队列、尸检登记和拉丁裔参与；并继续提供 为超过25项ADRC附属、独立资助的研究提供基础设施，包括USC Investigator- 启动了由NIH资助的临床研究。核心是一个集成的、协作的团队，包括医生(Lon 施奈德，海伦娜·崔，约翰·林曼，伊丽莎白·乔，索尼娅·帕卢奇克)，神经心理学家(莉娜·奥拉齐奥， 和其他调查人员(侯赛因·亚辛、朱迪·帕、迈克尔·哈林顿)。 它的具体目标是：1)与ADRC的其他核心合作，通过以下方式支持ADRC的中心主题 招募和维护血管风险队列；2)招募和维护注重种族多样性的队列 关于拉丁裔个人，并强调血管和代谢风险、ADRC参与和附属基金 研究；3)招募和维护脑研究研究队列，并与其他核心合作共享标本； 4)执行NACC统一数据集(UDS)年度评估，向NACC提交数据，促进 国家数据库，促进合作研究和数据共享；5)促进南加州大学的参与和 在国家协作研究中发挥领导作用，招募、留住与红十字委员会有关联的国家和地区的参与者 多中心项目；6)加强招聘，促进痴呆症预防工作和转化性研究 与ORE核心合作的机会，特别是包括来自Latinx和 代表不足的群体，来自南加州大学资助的阿尔茨海默病中心(CADC)，以及 Roybal综合保健诊所；以及7)支持神经成像和生物流体生物标记物研究。

Abstract The Clinical Core serves the USC ADRC’s themes, cerebrovascular and metabolic contributions to cognitive impairment; vascular and metabolic risk factors in cognitive decline; Alzheimer pathogenesis; and the prevention and treatment of Alzheimer-related disorders. The Core’s three overarching objectives are to: 1) develop and maintain a vascular risk factors cohort; 2) catalyze local, clinical and translational research, including early phase clinical trials; 3) provide expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The Core addresses many important goals of the 2011 National Alzheimer Project Act (NAPA): translational tools, infrastructure, trial design and conduct, novel drug targets, research on caregiver support, recruitment and citizen engagement, biomarkers, health disparities, data sharing, and enabling technologies. The Core enrolls and retains the primary ADRC cohorts, i.e., the Vascular Cohort Study, Brain Research (autopsy) Study, and participants co-enrolled in Affiliated-Studies. The core performs standard evaluations and diagnoses, oversees neuroimaging and blood and CSF biomarker collection. For this renewal, the core plans to increase the vascular cohort, enrollment for autopsy, and Latinx participation; and continue to provide infrastructure for over 25 ADRC-affiliated, independently-funded research studies including USC Investigator- initiated NIH-funded clinical studies. The core is an integrated, collaborative team, including physicians (Lon Schneider, Helena Chui, John Ringman, Elizabeth Joe, Sonia Pawluczyk), neuropsychologists (Lina D’Orazio, Carol McCleary), and other investigators (Hussein Yassine, Judy Pa, Michael Harrington). Its specific aims are to: 1) collaborate with the other ADRC cores to support the ADRC’s central theme by recruiting and maintaining the vascular risk cohort; 2) recruit and maintain an ethnically diverse cohort focusing on Latinx individuals and emphasizing vascular and metabolic risk, ADRC participation, and affiliated funded studies; 3) recruit and maintain a the Brain Research Study cohort and work with other cores to share specimens; 4) perform annual NACC Uniform Data Set (UDS) evaluations, submit data to NACC, promote an integrated national database, facilitate collaborative research and data sharing; 5) advance USC’s participation and leadership in national collaborative studies by recruiting, retaining participants in ADRC-affiliated national and multicenter projects; 6) enhance recruitment and promote dementia prevention efforts and translational research opportunities in collaboration with the ORE core that particularly includes participants from Latinx and underrepresented groups, and from the USC California-funded Alzheimer’s Disease Centers (CADC), and Roybal Comprehensive Healthcare Clinic; and 7) support neuroimaging and biofluid biomarker studies.