Core B: Recruitment and Sample Collection

摘要-招募和样本采集核心B 核心B将负责RESPOND队列的招募和样本采集，以提供 所有项目的必要数据和生物标本。核心将招募RESPOND队列， 2015-2018年期间诊断出10，000名患有PCa的AA男性，并提供关于社会压力和联系的调查数据 用于项目1的地理编码指示物，用于项目2的生殖系DNA提取的唾液，以及用于项目2的肿瘤组织。 项目3和4。从这个队列中获得的数据和生物标本将提供前所未有的见解 与AA男性PCa攻击性相关的因素。更具体地说，核心将协调 在7个州的9个癌症登记中心进行招募，提供样本选择说明，以确保 按临床特征和风险列出的非裔美国人（AA）前列腺癌（PCa）病例的必要分布 小组，以光学扫描的形式制定和预先测试简短的基线调查， 制定初步接触和病例后续行动规程并使之标准化，以达到答复率 目标以及第二次接触，以获得唾液样本，HIPAA形式，和组织块。协议 将唾液和组织样本以及来自调查、登记和外部的数据处理和交付至核心C 还将协调与核心D的联系。核心将提供印刷的调查表、小册子和通讯 向现场提供调查答复的光学扫描和外部数据链接（项目1）。 核心小组必须集中协调招募和样本收集工作，这是一个关键问题， 计划项目的需要。由于有多个招募地点，协议的标准化至关重要 确保各研究中心的可比数据收集和招募。此外，核心将监测进展情况， 通过每周电话会议了解征聘工作，并能够发现问题和解决 确保项目的目标得以实现。此外，常规 登记册网站之间的沟通将提供有关方法的信息共享， 所有网站的生产力。因此，核心将提高效率，标准化和数据质量， 整个项目计划。

Abstract – Recruitment and Sample Collection Core B Core B will be responsible for recruitment and sample collection for the RESPOND cohort to provide the necessary data and biological specimens for all of the Projects. The Core will recruit the RESPOND cohort of 10,000 AA men with PCa diagnosed between 2015-2018 and provide survey data on social stress and linkage geocoded indicators for Project 1, saliva for germline DNA extraction for Project 2, and tumor tissue for Projects 3 and 4. The data and biospecimens obtained from this cohort will provide unprecedented insights into factors associated with PCa aggressiveness in AA men. More specifically, the Core will coordinate recruitment among 9 cancer registry sites in 7 states, providing instructions for sample selection to assure the necessary distribution of African American (AA) prostate cancer (PCa) cases by clinical characteristics and risk groups, the development and pretesting of a brief baseline survey in an optically scannable format, development and standardization of protocols for initial contact and follow-up with cases to meet response rate goals as well as a second contact to obtain saliva samples, HIPAA forms, and tissue blocks. Protocols for handling and delivery of saliva and tissue samples to Core C and data from the survey, registries and external linkages to Core D will also be coordinated. The Core will provide printed surveys, brochures and newsletters to the sites and contract for optical scanning of survey responses and external data linkages (for Project 1). The importance of centralizing the coordination of recruitment and sample collection by the Core is a critical need for the Program Project. With multiple recruitment sites, the standardization of protocols will be essential for assuring comparable data collection and recruitment across sites. Also, the Core will monitor the progress of the recruitment effort through weekly conference calls and will be able to identify problems and address them in a timely manner to assure that the goals of the Program Project are being met. In addition, the regular communication among the registry sites will provide information sharing on methods that can improve productivity for all of the sites. Thus, the Core will enhance efficiencies, standardization and data quality for the entire Program Project.