Admin Core

心脏研究-脑老化计划（FHS-BAP）的使命是进行、促进和 促进对阿尔茨海默病的病因、发病机制、诊断、治疗和预防的高影响研究 疾病（AD）和相关病症。行政核心作为一个组织协调中心， 并协调临床，神经心理学和数据核心和项目1-3的研究活动， 最大限度地发挥协同作用、提高效率和生产力。在拟议的供资期间，行政核心将指导 丰富的FHS数据资源的扩展和扩展，并建立一个管理基础设施， 大大增加了世界各地其他研究人员对这一资源的共享和利用。完成这些 中心目标，行政核心将作为内部FHS-BAP活动之间的接口， 外部实体，并确保FHS-BAP活动符合所有核心和项目里程碑，并保持一致 与国家老龄化研究所（NIA）AD研究使命和完全符合所有人类受试者， 和NIH的科学诚信政策要求。我们将成立一个外部咨询委员会， 就FHS-BAP优先事项的制定和执行提供建议，并积极主动地识别机会， 让我们站在前瞻性科学的前沿。执行行政核心使命的关键是 对整个FHS-BAP进行适当的财务监督，跟踪所提供材料的处置情况， FHS-BAP的成果支持研究（出版物和资助活动），并在以下方面取得进展： 满足东非共同体反馈的既定目标对于评估业务活动的有效性至关重要 在满足研究的优先事项和他们的监督和不断投入的改进有助于确保我们实现 我们的既定目标。此外，考虑并协调FHS-BAP与其他FHS的日常运营 研究计划（例如，NHLBI资助的FHS合同，以支持FHS队列的核心健康检查）和其他 在位于马萨诸塞州弗拉特的FHS诊所收集FHS参与者数据的辅助研究将 与内部咨询委员会（IAB）合作完成，由当地的BU教师组成，以更好地 解决时间敏感的后勤问题。行政核心还将促进新的创新AD研究 利用FHS-BAP通过试点项目计划产生的数据，鼓励拨款申请 从初级教师和博士后研究员，以及从建立教师谁是新的广告领域， 在整个BU和其他机构可能。将进一步努力促进创新的广告研究， 通过促进FHS-BAP研究者与 地方，国家和国际研究计划，代表FHS-BAP参加科学会议， 通过Data Core公布FHS-BAP数据访问和使用，并与BU Alzheimer协调 疾病中心主办研讨会和专题讨论会，重点是广告研究。

The mission of the Framingham Heart Study–Brain Aging Program (FHS-BAP) is to conduct, facilitate and promote high impact research on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer disease (AD) and related disorders. The Administrative Core serves as a focal organizational point to organize and harmonize research activities of the Clinical, Neuropsychology, and Data Cores and Projects 1-3 to maximize synergy, efficiency and productivity. In the proposed funding period, the Administrative Core will guide the extension and expansion of the rich FHS data resource and establish a management infrastructure that will greatly increase the sharing and utilization of this resource by other researchers worldwide. To accomplish these central goals, the Administrative Core will serve as the interface between internal FHS-BAP activities and external entities, and ensure that FHS-BAP activities meet all Core and project milestones and are consistent with the National Institute of Aging (NIA) AD research mission and in full compliance with all human subjects, and scientific integrity policy requirements of the NIH. We will form an External Advisory Committee (EAC) to advise on the formulation and execution of FHS-BAP priorities and proactively identify opportunities that will keep us on the forefront of forward-thinking science. Key to executing the Administrative Core's mission is to provide appropriate financial oversight of the entire FHS-BAP, track the disposition of materials provided and the outcomes of FHS-BAP supported research (publications and funded activities) and present progress in meeting the stated aims to the EAC feedback will be critical in assessing effectiveness of operational activities in meeting research priorities and their oversight and continuous input for improvements help ensure we achieve our stated goals. Additionally, consideration and coordination of FHS-BAP day-to-day operations with other FHS research programs (e.g., NHLBI funded FHS contract to support core health exams of FHS cohorts) and other ancillary studies that are collecting data from FHS participants at the FHS clinic based in Framingham, MA will be done in collaboration with an Internal Advisory Board (IAB), consisting of locally based BU faculty to better address time-sensitive logistical issues. The Administrative Core will also promote new innovative AD research using data generated by the FHS-BAP through a pilot project program that will encourage grant applications from junior faculty and postdoctoral fellows, as well as from established faculty who are new to the AD field, throughout BU and possibly other institutions. Additional efforts to foster innovative AD research will be facilitating cross-core/project interactions by promotion of collaborations between FHS-BAP investigators with local, national, and international research programs, by representing the FHS-BAP at scientific meetings and publicizing FHS-BAP data access and use through the Data Core and coordinating with the BU Alzheimer Disease Center to host seminars and symposia focused on AD research.