CORE A: Participant Measures and Assessments

核心A.参与方的措施和评估 摘要/摘要 在ASPREE研究过程中，大量的临床、身体功能、认知和生活质量 训练有素的工作人员从19,114名参与者那里收集了数据(约2,600万个数据值)，结果显示 参与者留存率(82%，在研究结束时完全参与)、合规性(总体为74%)和数据 质量(99.6%的准确率)。该核心将建立在ASPREE业务成功的基础上，并提供方法论 通过协调、指导和管理为所有与参与者相关的研究活动提供运营支持 在ASPREE-XT中常规进行的生理和神经心理评估和问卷调查 来自美国和澳大利亚的参与者。核心服务将确保质量、准确性和彻底性 通过执行全面的标准作业程序从参与者那里收集数据 (标准操作程序)，并确保遵守标准操作程序，两国的工作人员将在开始学习前接受培训 活动(请参阅管理核心)。通过核心A的活动提供的数据是所有项目的临床联系， AS核心A将向核心B提供临床终点触发以进行后续跟进。提供的纵向表型数据 核心A关于ASPREE-XT参与者对于实现这一总体目标也是至关重要的 U19通过完成项目分析。具体地说，收集与癌症有关的信息 筛查、癌症发病率、进展和结果是项目1(癌症)的关键。集合 认知数据、抑郁和痴呆症终点对于评估痴呆症和轻度认知是必不可少的 项目2(痴呆症)中的损害结果。日常生活基本活动、身体机能、疲惫和 将收集体力活动数据，以评估项目3(残疾)的残疾和脆弱程度。 因此，U19的成功取决于将作为该核心的一部分收集的数据。 0

CORE A. PARTICIPANT MEASURES AND ASSESSMENTS SUMMARY/ABSTRACT During the course of the ASPREE study, a vast amount of clinical, physical function, cognitive and quality of life data (~26 million data values) were collected from 19,114 participants by trained staff, resulting in excellent participant retention (82% with full involvement at the end of the study), compliance (74% overall) and data quality (99.6% accuracy). This Core will build on the operational success of ASPREE and provide methodological and operational support for all participant-related study activity by coordinating, directing and managing the physiological and neuropsychological assessments and questionnaires conducted routinely in ASPREE-XT participants in both the U.S. and Australia. The Core services will ensure quality, accuracy and thoroughness of data collection from participants through the implementation of comprehensive Standard Operating Procedures (SOPs) and to ensure adherence to SOPs, staff in both countries will be trained prior to commencement of study activity (see Admin Core). Data provided through the activities of Core A are the clinical nexus for all projects, as Core A will provide clinical endpoint triggers to Core B for follow-up. The longitudinal phenotypic data provided by Core A about ASPREE-XT participants will also be of vital importance for addressing the overall aims of this U19 through completion of Project analyzes. Specifically, the collection of information related to cancer screening, cancer incidence, progression, and outcomes are crucial for Project 1 (Cancer). Collection of cognitive data, depression and dementia endpoints are essential for assessing dementia and mild cognitive impairment outcomes in Project 2 (Dementia). Basic activities of daily living, physical function, exhaustion and physical activity data will be collected for assessment of disability and frailty for Project 3 (Disability). Consequently, the success of the U19 hinges upon the data that will be collected as part of this Core. 0