Studies of Populations Exposed to Occupational Sources of Radiation

进行了一项生物剂量学研究，以确定83名飞行员（鉴于他们的宇宙辐射暴露水平增加）和51名飞行经验最少的大学教员之间是否存在染色体畸变频率的差异。航空公司飞行员和大学教师的对照组之间的平均易位频率没有差异，但是飞行员驾驶商用飞机的年数和易位频率有显着增加的趋势。此外，在调整年龄和飞行年数后，飞行员个人诊断程序的辐射暴露与易位频率呈正相关。一些饮食和维生素补充剂也与易位频率有关。 1982年，REB发起了一项全国性的队列研究，研究了146,022名美国放射科技术人员的所有癌症发病率和死亡率。S.在1926-1980年期间获得认证的放射技术人员。女性占73%。 从工作历史数据（收集于1983-89年、1994-98年、2003-2005年和2012年开始）沿着追踪和匹配死亡信息，我们发现在1950年之前首次工作的技术人员中，乳腺癌、慢性淋巴细胞白血病以外的白血病、皮肤基底细胞癌、黑色素瘤和循环系统疾病的发病风险显著升高，而在1960年之前首次工作的人中，甲状腺癌的发病率也有所上升。第一次全面的历史职业剂量重建的反应率和发展非常高，为研究职业性长期低至中等剂量辐射照射对乳腺癌和甲状腺癌的影响提供了难得的机会，这两种癌症是最敏感或最不敏感的。

Markers of Cosmic Radiation Exposure Among Flight Crew A biodosimetry study study was conducted to determine if there were differences in the frequency of chromosome aberrations by assess cosmic radiation exposure and frequency of chromosome aberrations by fluorescence in situ hybridization among 83 pilots (given their increased levels of cosmic radiation exposure) and 51 university faculty with minimal flying experience. The mean frequency of translocations did not differ between the airline pilots and a comparison group of university faculty, however there was a significant increasing trend among the pilots for number of years flying commercial aircraft and translocation frequency. In addition, radiation exposure from personal diagnostic procedures among the pilots was positively associated with translocation frequencies after adjustment for age and number of years flying. Some diet and vitamin supplements were also associated with translocation frequency. Cancer and Other Mortality Risks in a Cohort of U.S. Radiologic Technologists In 1982, the REB, initiated a nationwide cohort study of all cancer incidence and mortality among 146,022 U. S. radiologic technologists who were certified during 1926-1980. The cohort with 73% females. From work history data (collected 1983-89, 1994-98, 2003-2005, and beginning in 2012) along with tracing and matching with death information, we found significantly elevated incidence risks for breast cancer, leukemias other than chronic lymphocytic leukemia, basal cell carcinoma of the skin, melanoma and circulatory diseases among technologists first working before 1950, and a suggested increase in thyroid cancer in those first working before 1960. The , and very high response rates and development of the first comprehensive historical occupational dose reconstruction offers a rare opportunity to study effects of occupational protracted low- to moderate-dose radiation exposure on breast and thyroid cancer, the two most sensitive or