Epidemiological and Statistical Methods Core (ESC)

项目总结 儿科HIV/AIDS队列研究(PHACS)是一个具有多个观察点的大型多站点网络 研究旨在评估以人群为基础的干预措施的长期有效性和安全性 围产期艾滋病毒传播和艾滋病毒进展，并为艾滋病毒缓解/治疗战略提供信息。PHACS 研究项目已经产生并将继续从各种不同的健康决定因素收集数据 来源和通过不同的方法，包括临床、社会、基因组、微生物组和成像数据。一群人 因此，将提议进行概念表和分研究，需要专门的流行病学和 统计专业知识，从有效的研究设计、因果推理方法、深度学习 算法、生物信息学和综合微生物组信息学，以提供将被 由PHACS数据资源核心(DRC)进行。随着我们继续增加我们广泛的PHAC 数据库中，可能会出现新的和具有挑战性的问题，这些问题可能需要开发创新的 研究设计和分析方法，特别是在儿科和围产期流行病学领域。正在进行中 将需要对PHACS流行病学家进行关于这些和其他方法创新的培训 统计学家。还将开展流行病学和统计学基本原理方面的继续教育 为了进行有效的协作研究，所有PHACS调查人员都需要。 为了满足这些需求并促进有效和高效的儿科和围产期艾滋病毒研究 研究项目和任何有重点的新兴研究试点，PHACS流行病学和统计学 方法建立CORE(ESC)：(1)提供专门的流行病学和统计服务； 支持和资源；(2)促进新的流行病学和统计学的开发和应用 方法；及(3)支持流行病学和统计学方法的持续教育 基于网络的早期职业调查人员培训和指导。

PROJECT SUMMARY The Pediatric HIV/AIDS Cohort Study (PHACS) is a large-scale multi-site network with multiple observational studies aimed to evaluate the long-term effectiveness and safety of population-based interventions to prevent perinatal HIV transmission and HIV progression and inform HIV remission/cure strategies. The PHACS Research Projects have generated and will continue to gather data on health determinants from various sources and via diverse methods including clinical, social, genomic, microbiome, and imaging data. A multitude of concept sheets and sub-studies will therefore be proposed requiring specialized epidemiological and statistical expertise, ranging from efficient study design, causal inference methodology, deep learning algorithms, bioinformatics, and integrative microbiome informatics, to inform data analyses that will be conducted by the PHACS Data Resources Core (DRC). As we continue to add to our extensive PHACS database, new and challenging problems are likely to arise that may necessitate the development of innovative study designs and analytic methods, particularly in the fields of pediatric and perinatal epidemiology. Ongoing training will be required on these and other methodological innovations for PHACS epidemiologists and statisticians. Continuing education on fundamental epidemiological and statistical principles will also be required for all PHACS investigators in order to conduct effective collaborative research. To address these needs and promote valid and efficient pediatric and perinatal HIV research within the Research Projects and any focused Emerging Research Pilots, the PHACS Epidemiological and Statistical Methods Core (ESC) has been established to: (1) provide specialized epidemiological and statistical services, support, and resources; (2) promote the development and application of novel epidemiological and statistical methods; and (3) support continuing education in epidemiological and statistical methods through in-person or web-based training and mentorship of early career investigators.