The Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

总体汇总 在过去，肥胖和肾结石疾病的患病率在美国一直在稳步上升 几十年草酸钙结石是最常见的类型，包括肥胖人群。那里 越来越多的证据表明，肥胖与尿草酸排泄增加有关， 草酸钙结石的形成。为了解决这个问题，我们建立了一个研究中心， 首字母缩略词COOKS（肥胖和草酸盐肾结石研究中心）。本中心提供一个 新科学研究的平台以及教育和信息传播的基础设施。的 一项研究项目将集中在确定原因增加尿草酸排泄在肥胖钙 草酸盐结石形成者。这将通过建立一个多机构、协同、跨学科的 小组，包括在肾结石研究，肥胖，营养和肾和 胃肠生理学该科学研究项目将检查胃肠道和肾脏的影响 草酸盐处理和内源性草酸盐合成对正常BMI和肥胖成人尿草酸盐排泄的影响 草酸钙肾结石形成者。将使用现有的和新的技术。建立 技术将包括扩展的饮食研究，其中草酸盐，钙和其他营养素的水平密切相关。 控制。新技术将涉及代谢标记，以跟踪草酸盐的处理和合成， 最先进的成像技术。行政核心将监督研究和教育活动 的库克。它还将负责财务管理，维持合作， 与其他相关NIDDK赞助的中心和项目官员进行沟通。教育充实 该计划将继续广泛开展。已建立的网站将扩大，并与UAB和 德克萨斯大学西南分校该网站将促进教育活动和传播信息 泌尿科社区，其他相关的调查人员和公众。产生的数据应该会增加我们的 了解肥胖和尿草酸之间的关系，所涉及的因素，并作为一个 该平台旨在开发预防肥胖患者草酸钙肾结石的新疗法。

OVERALL SUMMARY The prevalence of both obesity and kidney stone disease has been steadily increasing in the U.S. over the past several decades. Calcium oxalate stones are the most common type, including within the obese cohort. There is mounting evidence that obesity is associated with increased urinary oxalate excretion, an important risk factor for calcium oxalate stone formation. To address this issue, we have established a research center that was given the acronym COOKS (Center for research on Obesity and Oxalate Kidney Stones). This Center provides a platform for novel scientific research and the infrastructure for education and dissemination of information. The research project will focus on defining the reasons for the increased urinary oxalate excretion in obese calcium oxalate stone formers. This will be accomplished by establishing a multi-institutional, synergistic, interdisciplinary group, including scientists with unique backgrounds in kidney stone research, obesity, nutrition, and renal and gastrointestinal physiology. The scientific research project will examine the influence of gastrointestinal and renal oxalate handling, and endogenous oxalate synthesis on urinary oxalate excretion in normal BMI and obese adult calcium oxalate kidney stone formers. Both established and novel techniques will be utilized. Established techniques will include extended dietary studies where levels of oxalate, calcium and other nutrients are tightly controlled. Novel techniques will involve metabolic labelling to follow oxalate handling and synthesis, and state of the art imaging techniques. The administrative core will provide oversight of research and educational activities of COOKS. It will also be responsible for financial management, maintenance of collaborations, and communication with other pertinent NIDDK-sponsored centers and program officials. The education enrichment program will continue to be broad based. The established website will be expanded and linked to both UAB and the University of Texas Southwestern. This website will promote educational events and disseminate information to the Urologic community, other pertinent investigators and the public. The data generated should increase our understanding of the relationships between obesity and urinary oxalate, the factors involved, and serve as a platform to develop novel therapies for calcium oxalate kidney stone prevention in obese individuals.