An ImageDx based multi-scale platform for tissue, cellular, molecular, and genomic visualization

本提案的目标是开发一种多尺度可视化工具，能够摄取和可视化组织，细胞和分子图像数据以及空间基因组剖面信息，并将该工具提交给关键利益相关者小组以获得反馈。该研究工具将被开发为ImageDx多尺度模块，添加到目前的Reveal Biosciences商业ImageDx模块组合中，提供全面的计算病理学服务。研究人员将使用这种多尺度工具来更好地了解疾病的发展和演变。使用我们的设计驱动开发流程将完成以下目标：(1)创建-可视化动画原型界面和后端开发的3次迭代，与利益相关者的反馈交替进行；(2)原型——用功能线框图重复迭代过程；(3) Sprint—基于启发式可用性方法的可用性调查的端到端产品构建。项目的最终成果是一个ImageDx多尺度模块，该模块通过与QuantumCyte公司合作获得的四个数据尺度进行了验证。通过用户反馈，该模块将展示有效的组织、细胞、分子和基因组尺度的多尺度可视化。第二阶段将增加与额外数据规模的集成，执行更大规模的beta测试，并开发sop和用户文档。

The objective of this proposal is to develop a multi-scale visualization tool capable of ingesting and visualizing tissue, cellular, and molecular image data together with spatial genomic profile information and presenting this tool to a panel of key stakeholders for feedback. The research tool will be developed as the ImageDx Multi-Scale module, adding to the current Reveal Biosciences portfolio of commercial ImageDx modules providing comprehensive computational pathology services. Such a multi-scale tool will be used by researchers to acquire an improved understanding of the development and evolution of disease. The following Aims will be completed using our Design Driven Development process: (1) Create – 3 iterations of visualization animated prototype interface and back-end development alternating with stakeholder feedback; (2) Prototype – repeat iterative process with functional wireframes; and (3) Sprint - end-to-end product build with usability surveys based on heuristic usability methodology. The end of project deliverable is an ImageDx Multi-Scale module validated with four data scales acquired in partnership with QuantumCyte, Inc. Through user feedback, the module will demonstrate effective multi-scale visualization of tissue, cellular, molecular, and genomic scales. Phase II will add integration with additional data scales, perform larger scale beta testing, and develop SOPs and user documentation.