Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses

摘要 非疟疾急性未分化发热(AUFIs)是#年发病率和死亡率的重要原因。 在拉丁美洲，登革热类疾病的发病率近年来急剧增加。在大多数情况下 在低收入和中等收入国家，只有少数“登革热”病例通过实验室检测和 因此，许多其他病原体仍然隐藏在登革热的“保护伞”之下。缺乏适当的培训 科学家和卫生保健工作者被认为是诊断AUFIs的主要障碍之一。至 填补这一空白，我们的D43全球传染病研究培训计划于2016年启动，目标是 组建一支研究非疟疾急性未分化发热病(AUFIs)的强大科学家团队 哥伦比亚。从那时起，该项目填补了一个重大空白。在过去的五年里，我们完成了 培训哥伦比亚教员、博士后和博士后，并进行短期培训 关于赠款撰写和手稿准备的培训。该计划包括短期、中期和长期 研究培训，而且超出了预期(见进度报告)。过去的五年让我们 找出其他差距、挑战和机遇。我们新提议的活动将建立在我们的 取得成就并继续建设能力和培训一批新的哥伦比亚教员，博士 研究新出现的人畜共患病和媒介传播疾病的学生和博士后研究员。我们将扩大规模 我们D43培训计划的重点是应对呼吸道病毒，包括SARS-CoV-2和流感 病毒。我们将纳入基础生物医学硕士研究生的培训 并实施关于新分子和生物信息学方法、电子显微镜、新诊断方法的培训 方法、赠款写作、科学写作、科学研究中的伦理和生物安全，以及哥伦比亚大学， 博士生和博士后研究员，研究领导力。我们精心设计的计划包括：1)在第一年 2、我们将支持对6名哥伦比亚教职员工进行中期培训，培训对象为“培训者” 方法，2)在一年级和二年级，我们将招募和支持在国内长期培训的硕士研究生 在哥伦比亚人的指导下，对新出现的人畜共患病和病媒传播疾病感兴趣 计划学院，3)在3至5年内，我们将招聘和支持博士和博士后的长期培训 在美国的高级研究方法、科学写作、生物安全和生物伦理方面的研究员，以及，4)我们将 在哥伦比亚开展短期国别培训，以确保适当实施方法；以及 还举办具体的研讨会。我们会继续透过以下途径，支持区内各院校的培训- 美国教职员工的国别访问和资金将用于试点和重新插入小额赠款 完成培训。一个重要的计划成果是提高对这些疾病的认识。 人类和兽医卫生专业人员以及公共卫生当局。

Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases are confirmed by laboratory testing and therefore many other pathogens remain hidden under the dengue “umbrella”. Lack of proper training among scientists and health care workers was recognized as one of the major obstacles in the diagnosis of AUFIs. To fill this gap, our D43 Global Infectious Disease Research Training Program was launched in 2016, with the goal of forming a strong team of scientists studying non-malarial acute undifferentiated febrile illnesses (AUFIs) in Colombia. Since then, the program has filled a major gap. Over the past five years, we completed advanced training of Colombian Faculty members, predoctoral and postdoctoral students, and conducted short-term training on grant writing and manuscript preparation. The program encompassed short, medium, and long-term research training, and it has exceeded expectations (see Progress Report). The past five years has allowed us to identify additional gaps, challenges, and opportunities. Our new proposed activities will build on our accomplishments and continue to build capacity and train a new group of Colombian Faculty members, PhD students and postdoctoral fellows studying the emerging zoonotic and vector-borne diseases. We will expand the focus of our D43 training program to address respiratory viruses, including SARS-CoV-2 and influenza viruses. We will incorporate training of master’s students enrolled in the Master’s in Basic Biomedical Sciences and implement training on novel molecular and bioinformatic methods, electron microscopy, novel diagnostic methods, grant writing, scientific writing, ethics in scientific research, and biosafety, and for Colombian Faculty, PhD students and postdoctoral fellows, research leadership. Our carefully designed plan includes: 1) In Years 1 and 2, we will support medium-term training of six Colombian Faculty members under a “train the trainer” approach, 2) In Years 1 and 2, we will recruit and support in-country long-term training of master’s students interested in emerging zoonotic and vector-borne diseases working under the mentorship of the Colombian Program Faculty, 3) In Years 3 through 5, we will recruit and support long-term training of PhD, and postdoctoral fellows in the US in advanced research methodologies, scientific writing, biosafety, and bioethics, and, 4) we will conduct short-term in country training in Colombia to ensure appropriate implementation of methodologies, and also conduct specific workshops. We will continue to support training across institutions in the region through in- country visits of US Faculty members and funds will be available for pilot and reinsertion small grants after completion of training. An important planned outcome is the increased awareness of these diseases at the level of human and veterinary health professionals, as well as public health authorities.