Clinical Research Resources and Facilities

摘要/摘要 改善医疗服务不足的人的医疗保健，包括我们的西班牙裔人口，他们受到 流行的疾病，如癌症、心脏代谢疾病和传染病，仍然是一个重大挑战。 在临床和翻译研究中，种族和少数民族的代表性有限是一个重要的 这一挑战限制了结果的普适性，并导致了这些地区不成比例的疾病负担 组。有必要增加西班牙裔研究参与者和研究人员在 临床和转化性研究，以提高研究结果的概括性和适用性 找出特定种族的差异，这可能会导致治疗指南的改变，并促进对 这群人。联盟的临床研究资源和设施核心处于有利地位，可以解决 拉美裔受试者参与临床研究的差距和拉美裔人数的增加 参与临床和转化性研究的科学家，因为他们可以接触到这两个地区的常住人口 西班牙裔参与者和西班牙裔科学家的代表性不足。临床研究资源的目标 和设施核心(CRRF)是为了促进和加强安全和经济高效的临床和翻译 研究，重点是拉美裔和医疗服务不足人群的健康问题。具体的 目标是提供一个跨以西班牙裔为主的理念司法管辖区的协调结构，以支持 协作的多学科和跨学科的临床和转化性研究，并增加参与和 保留西班牙裔研究参与者。这项提议背后的理由是，建立和 整合多个为拉美裔服务的机构和团体的资源，配备文化上的辅音 在拉美裔美国司法管辖区，调查人员和工作人员将克服影响参与的许多障碍 拉美裔美国人的研究，这反过来将转化为更多的研究和更多关于流行疾病的数据 在西班牙裔美国人中。我们的目标将通过三个具体目标来实现：1)建立综合网络 临床和转化性研究资源和设施，以提高成本效益，多学科和跨学科 在拉美裔人群中普遍存在的健康状况方面的学科研究；2)促进和增加 从服务不足的西班牙裔社区招聘和保留研究参与者；3)确保 对人类受试者进行的临床和转译研究是安全的，而且质量最高。当这些目标是 完成后，我们将影响加勒比拉美裔作为研究参与者和调查人员的代表性。

Abstract/Summary Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. Limited representation of racial and ethnic minorities in clinical and translational research is an important challenge that limits the generalizability of results and contributes to the disproportionate disease burden in these groups. There is a need to increase the representation of Hispanic research participants and researchers in clinical and translational research to improve the generalizability and applicability of research findings and identify ethnic-specific differences that could dictate changes in treatment guidelines and facilitate research in this population. The Clinical Research Resources and Facilities Core of the Alliance is well positioned to address the gap in the participation of Hispanic subjects in clinical research and increase the number of Hispanic scientists participating in clinical and translational research, given their access to resident populations of both underrepresented Hispanic participants and Hispanic scientists. The goal of the Clinical Research Resources and Facilities Core (CRRF) is to facilitate and enhance safe and cost-effective clinical and translational research, with an emphasis in health problems of Hispanics and medically underserved populations. The specific objective is to provide a coordinated structure across a predominantly Hispanic IDeA jurisdiction to support collaborative multi-and interdisciplinary clinical and translational research and increase the participation and retention of Hispanic research participants. The rationale that underlies this proposal is that establishing and integrating resources across multiple Hispanic-serving Institutions and groups, staffed by culturally consonant investigators and staff, in a Hispanic US jurisdiction, will overcome many of the barriers that impact participation of Hispanics in research, which in turn will translate into more studies and more data about diseases prevalent in Hispanics. Our objective will be accomplished through three specific aims: 1) Establish an integrated network of clinical and translational research resources and facilities to enhance cost-effective, multidisciplinary and inter- disciplinary research, in health conditions prevalent among Hispanic populations; 2) Facilitate and increase the recruitment and retention of research participants from underserved Hispanic communities; 3) Ensure that clinical and translational research with human subjects is safe and of the highest quality. When these aims are completed we will impact the representation of Caribbean Hispanics as study participants and as investigators.