Optimizing Implementation in Cancer Control: OPTICC - Implementation Lab Core

实施实验室核心摘要 实施实验室核心将建立和协调一个由不同的临床和社区 可以进行OPTICC中心实施科学（IS）研究，实施癌症控制 循证干预（EBI），并塑造中心的研究议程。实施实验室拥有 招募了五个研究就绪的实验室合作伙伴，包括我们华盛顿5个州的不同临床研究中心， 怀俄明州、阿拉斯加州、蒙大拿州和爱达荷州（WWAMI）地区。实验室合作伙伴都是已建立的网络 具有多站点协作研究和/或质量改进工作的经验。实验室包括主要 护理和癌症护理诊所，门诊和住院设置，以及农村和城市环境， 向传统上得不到充分服务的人口提供保健服务，从而能够开展解决保健差距问题的实施研究。 实施实验室有四个具体目标。目标1是建立行政程序，以确保 实施实验室的有效，高效的协调，促进生产，互利 实验室合作伙伴和OPTICC中心之间的合作。目标2是支持 实施实验室合作伙伴和OPTICC研究领导多个并发创新实施 研究，措施和方法研究，以及针对优化EBI三个阶段的试点研究 在癌症控制中的应用。目标3是开发基础设施和流程，以支持大规模的 实施研究，涉及实验室合作伙伴之间的数据共享和协调程序， 受试者、数据安全和监测。目标4是监测实施实验室合作伙伴正在进行的癌症控制 EBI实施计划;跟踪中心支持的EBI的进展、成功和挑战 实施工作;并确定新出现的实施优先事项，为中心的研究议程提供信息。 我们的实验室合作伙伴的实地实施优先事项、举措和挑战将推动OPTICC 研究者实施研究的目的和方法。实施实验室的预期成果包括 在临床和社区环境中改进癌症控制EBI的实施;“学习实验室” 通过该平台，实验室合作伙伴参与同行学习，并获得实践工具、指导和发现 从该中心的研究，和OPTICC研究人员了解现实世界的实施计划， 推动信息系统的挑战;以及一个研究基础设施，可以参与更大的，后续的，多站点， 多层次的研究，将来自OPTICC和其他先进的和发展中的中心。

IMPLEMENTATION LABORATORY CORE SUMMARY The Implementation Laboratory Core will establish and coordinate a network of diverse clinical and community sites that can conduct the OPTICC Center’s implementation science (IS) studies, implement cancer control evidence-based interventions (EBIs), and shape the Center’s research agenda. The Implementation Lab has recruited five research-ready Lab Partners that include diverse clinical sites across our 5-state Washington, Wyoming, Alaska, Montana, and Idaho (WWAMI) region. The Lab Partners are all established networks experienced with collaborative multi-site research and/or quality improvement efforts. The Lab includes primary care and cancer care clinics, outpatient and inpatient settings, and rural and urban environments that provide care to traditionally underserved populations, permitting implementation studies that address health disparities. The Implementation Lab has four specific aims. Aim 1 is to establish administrative procedures to ensure effective, efficient coordination of the Implementation Lab and promote productive, mutually beneficial collaborations between Lab Partners and the OPTICC Center. Aim 2 is to support collaboration between Implementation Lab Partners and OPTICC Study Leads in multiple, concurrent innovative implementation studies, measures and methods studies, and pilot studies that address three stages of optimizing EBI implementation in cancer control. Aim 3 is to develop infrastructure and processes to support large-scale implementation studies that involve data sharing across Lab Partners and harmonized procedures for human subjects, data safety and monitoring. Aim 4 is to monitor Implementation Lab Partners’ ongoing cancer control EBI implementation initiatives; track progress, successes and challenges of Center-supported EBI implementation efforts; and identify emerging implementation priorities to inform the Center’s research agenda. Our Lab Partners’ on-the-ground implementation priorities, initiatives and challenges will drive OPTICC investigators’ implementation study aims and methods. The Implementation Lab’s expected outcomes include improved implementation of cancer control EBIs in clinical and community settings; a “learning laboratory” through which Lab Partners engage in peer learning and gain access to practice tools, guidance, and findings from the Center’s studies, and OPTICC investigators learn about real-world implementation initiatives and challenges that drive IS; and a research infrastructure that can participate in the larger, follow-on, multi-site, multi-level studies that will emanate from OPTICC and other Advanced and Developing Centers.