Resource and Service Center

摘要 采用模式生物的已发表研究的重现性差，研究设计缺乏透明度 已经成为科学界关注的领域。这些问题可以深刻地影响解释 临床前研究，必须解决的基因组编辑技术允许快速建模的患者- 特定的、与疾病相关的遗传变异，并以患者风险评估的形式转化为临床， 管理和治疗。可重复性问题的核心是模式生物本身。稳定性 遗传背景、基因组完整性和基因工程等位基因的特异性的同一性， 由于使用相似但独立开发的模型或质量差异， 模型维护高质量动物生产和饲养的集中化和标准化 模型可以开始解决研究再现性和透明度的问题，并取得了很大成功 我们现有的动物模型项目。美国精密仪器研究中心的资源和服务部门 医学建模将建立在未诊断疾病网络的现有专业知识和基础设施之上 模式生物筛选中心果蝇核心在中国科学院，中国科学院基因敲除小鼠的生产和 表型分析网站，体细胞基因组编辑计划的BCM-水稻小动物测试中心， 和人类基因组测序中心的大型恒河猴序列资源，以（1）获取， 鉴定和维持高质量的蝇和鼠资源，（2）保存和分发蝇和鼠 资源，（3）协调中心为生物医学研究人员提供的收费服务活动，（4）沟通 中心资源和服务的可用性和质量，以及（5）制定程序，以评估 运营

ABSTRACT Poor reproducibility of published research employing model organisms and lack of transparency of study designs have become areas of concern for the scientific community. These issues can profoundly affect the interpretation of preclinical studies and must be addressed as genome editing technologies permit rapid modeling of patient- specific, disease-associated genetic variation and translation to the clinic in the forms of patient risk assessment, management, and treatment. At the heart of reproducibility issues are the model organism themselves. Stability and identity of the genetic background, genome integrity, and specifics of genetically engineered alleles often vary between studies due to use of similar but independently developed models or differences in the quality of model maintenance. Centralization and standardization of high-quality production and maintenance of animal models can begin to address issues with study reproducibility and transparency and has been highly successful for our existing animal modeling programs. The Resource and Service Section of the BCM Center for Precision Medicine Modeling will build on existing expertise and infrastructures of the Undiagnosed Diseases Network Model Organism Screening Center Drosophila Core at BCM, the BCM Knockout Mouse Production and Phenotyping site, the BCM-Rice Small Animal Testing Center for the Somatic Cell Genome Editing Program, and a large rhesus macaque sequence resource in the Human Genome Sequencing Center to (1) acquire, characterize, and maintain high-quality fly and mouse resources, (2) preserve and distribute fly and mouse resources, (3) coordinate Center fee-for-service activities for biomedical researchers, (4) communicate the availability and quality of Center resources and services, and (5) enact procedures to evaluate Section operations.