Wisconsin Exploratory Center for Interdisciplinary Research in Benign Urology

整体项目总结 下尿路症状(LUT)代表了一组不同的症状，具有较高的经济和 社会成本和对患者生活质量的显著影响。LUTS在美国的流行情况 范围在45%到70%之间，并随着年龄的增长而增加。某些LUT的医疗费用一直是 据报道，每年高达650亿美元。威斯康星探索中心的指导前提是 良性泌尿外科的跨学科研究表明，LUT可以得到更好的管理，尽管有所改进 初级护理和专科护理之间的协作。具体地说，威斯康星探索中心的调查人员 打算研究针对适当患者的有效治疗的创新策略。其中一个特别的 令人烦恼的LUTS是尿失禁，或非自愿排尿，这是一种常见的慢性疾病 影响到近一半的成年女性。虽然对这两种主要类型的尿路疾病有有效的治疗方法 大小便失禁(即压力性和紧张性大小便失禁)，有证据表明大多数患者 任何治疗，以及对那些这样做的人来说，治疗往往是不够的，症状仍然存在。第一项研究 威斯康星州探索中心的项目将把5名中心调查人员聚集在一起， 开发、实施和评估一种新的医疗系统护理路径的专业知识，用于治疗妇女 大小便失禁。通过使用患者报告的结果衡量标准改进对有症状患者的识别， 随后，逐步启动可用的治疗方法，我们希望更好地管理大小便失禁，改善 改善患者的症状，减少不适当的转诊。威斯康星州探索中心的行政管理 CORE将监督与研究项目和教育充实有关的所有活动 程序。教育充实计划将支持医学生的暑期研究体验 以及一系列研讨会，邀请了来自非传统背景的演讲者 泌尿生殖系统疾病。行政核心将促进与NIDDK和其他NIDDK的协调- 资助的项目和中心。它将确保人类受试者研究的监管合规性。这个 威斯康星州探查中心将从患者咨询中征求关于进展和战略的外部观点 小组和由机构领导层组成的咨询委员会。通过将成员聚集在一起 我们当地的科学家社区已经在研究良性泌尿生殖系统疾病并招募 有经验的科学家研究其他条件，以应用他们的专业知识和技术来研究 良性泌尿生殖系统疾病，威斯康星探索中心将加强 良性的泌尿生殖系统研究界，并促进该领域的科学研究。

OVERALL PROJECT SUMMARY Lower urinary tract symptoms (LUTS) represent a heterogeneous set of symptoms with high economic and social costs and significant effects on patients' quality of life. The prevalence of LUTS in the United States ranges between 45% and 70% and increases with age. Medical expenditures for certain LUTS have been reported to be as high as $65 billion per year. The guiding premise of the Wisconsin Exploratory Center for Interdisciplinary Research in Benign Urology is that LUTS can be better managed though improved collaboration between primary and specialty care. Specifically, the Wisconsin Exploratory Center investigators intend to investigate innovative strategies to target effective treatments to appropriate patients. One particularly bothersome LUTS is urinary incontinence, or the involuntary loss of urine, which is a common chronic condition affecting nearly half of adult women. While there are effective treatments for the two main types of urinary incontinence (namely, stress and urgency incontinence), there is evidence that most patients do not receive any treatment, and for those who do, treatment is often inadequate, and symptoms remain. The first research project of the Wisconsin Exploratory Center will bring together 5 Center investigators with the necessary expertise to develop, implement, and evaluate a novel health system care pathway for treating women with incontinence. With improved identification of symptomatic patients using patient-reported outcome measures, and subsequent, stepwise initiation of available therapies, we hope to better manage incontinence, improve patients' symptoms, and reduce inappropriate referrals. The Wisconsin Exploratory Center's Administrative Core will provide oversight for all activities related to the research project and the Educational Enrichment Program. The Educational Enrichment Program will support medical student summer research experiences and a seminar series that brings invited speakers from backgrounds that are non-traditional in benign genitourinary conditions. The Administrative Core will facilitate coordination with the NIDDK and other NIDDK- funded Programs and Centers. It will ensure regulatory compliance for human subjects research. The Wisconsin Exploratory Center will solicit outside perspectives on progress and strategy from a Patient Advisory Panel and from an Advisory Committee comprising institutional leadership. By bringing together members of our local community of scientists already investigating benign genitourinary diseases and recruiting experienced scientists investigating other conditions to apply their expertise and techniques to the study of benign genitourinary diseases, the Wisconsin Exploratory Center will enhance the intellectual infrastructure of the benign genitourinary research community and foster scientific research that advances the field.